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Soluble trail as a marker of efficacy of allergen-specific immunotherapy in patients with allergic rhinoconjunctivitis
Antalya Education and Research Hospital, Turkey.
Akdeniz University, Turkey .
Akdeniz University, Turkey .
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
2012 (English)In: Medical Science Monitor, ISSN 1234-1010, E-ISSN 1643-3750, Vol. 18, no 10, CR617-CR621 p.Article in journal (Refereed) Published
Abstract [en]


Allergic rhinitis is a common health problem affecting the immune system. The homeostasis of the immune system is regulated by apoptosis. In this study, serum circulating soluble TRAIL levels of allergic rhinoconjunctivitis patients before and after allergen-specific immunotherapy were evaluated.


The sTRAIL levels of pre- and post-treated allergic rhinoconjunctivitis patients (n=25) were compared to age- and sex-matched healthy individuals (n=25). sTRAIL levels were measured by ELISA. The skin prick test (SPT) results were recorded before and after treatment.


The sTRAIL levels between the pre-treated and control groups were significantly different (p<0.0001). However, there was no significant difference between the post-treated group and healthy individuals (p=0,801). SPT was a statistically significant difference between the values of the research group before and after immunotherapy (grasses mixture, barley mixture, Oleaauropeae, D. Pteronyssinus, D. farinae).


The sTRAIL levels were decreased after allergen-specific immunotherapy to healthy levels and may be of use as a marker of efficacy of immunotherapy in allergic rhinoconjunctivitis patients.

Place, publisher, year, edition, pages
Medical Science International Publishing , 2012. Vol. 18, no 10, CR617-CR621 p.
Keyword [en]
allergen-specific immunotherapy; sTRAIL levels; allergic rhinitis; skin prick test
National Category
Social Sciences
URN: urn:nbn:se:liu:diva-87230DOI: 10.12659/MSM.883488ISI: 000311590200013OAI: diva2:587365
Available from: 2013-01-14 Created: 2013-01-14 Last updated: 2014-10-28

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Bisgin, Atil
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