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Polarized Light Spectroscopy for Measurement of the Microvascular Response to Local Heating at Multiple Skin Sites
Linköping University, Department of Clinical and Experimental Medicine, Burn Center. Linköping University, Faculty of Health Sciences.
Östergötlands Läns Landsting, Sinnescentrum, Department of Plastic Surgery, Hand surgery UHL.
Linköping University, Department of Clinical and Experimental Medicine, Burn Center. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Plastic Surgery, Hand surgery UHL. Östergötlands Läns Landsting, Sinnescentrum, Department of Anaesthesiology and Surgery UHL.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Plastic Surgery, Hand surgery UHL.
2012 (English)In: Microcirculation, ISSN 1073-9688, E-ISSN 1549-8719, Vol. 19, no 8, 705-713 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To evaluate whether TiVi, a technique based on polarized light, could measure the change in RBC concentration during local heating in healthy volunteers. Methods: Using a custom-made transparent heater, forearm skin was heated to 42 degrees C for 40 minutes while the change in RBC concentration was measured with TiVi. The perfusion response during local heating was measured at the same time with Laser Doppler flowmetry. Results: Mean RBC concentration increased (91 +/- 34 vs. 51 +/- 34 A.U. at baseline, p less than 0.001). The spatial heterogeneity of the RBC concentration in the measured skin areas was 26 +/- 6.4% at baseline, and 23 +/- 4.6% after 40 minutes of heating. The mean RBC concentrations in two skin sites were highly correlated (0.98 at baseline and 0.96 after 40 minutes of heating). The change in RBC concentration was less than the change in perfusion, measured with LDF. Unlike with LDF, a neurally mediated peak was not observed with TiVi in most of the test subjects. Conclusions: TiVi is a valuable technique for measuring the microvascular response to local heating in the skin, and offers a high reproducibility for simultaneous measurements at different skin sites, provided carefully controlled experiments are ensured.

Place, publisher, year, edition, pages
Informa Healthcare / John Wiley and Sons , 2012. Vol. 19, no 8, 705-713 p.
Keyword [en]
tissue viability imaging; polarization light spectroscopy; local heating; red blood cell concentration; reproducibility
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-87225DOI: 10.1111/j.1549-8719.2012.00203.xISI: 000311373400004OAI: oai:DiVA.org:liu-87225DiVA: diva2:587381
Available from: 2013-01-14 Created: 2013-01-14 Last updated: 2017-12-06

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Tesselaar, ErikSjöberg, FolkeFarnebo, Simon

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Burn CenterFaculty of Health SciencesDepartment of Plastic Surgery, Hand surgery UHLDepartment of Anaesthesiology and Surgery UHLSurgery
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Microcirculation
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