Hierachically Structured Hollow Silica Spheres for High Efficiency Immobilization of Enzymes
2013 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Advanced Functional Materials, ISSN 1616-3028, Vol. 23, no 17, 2162-2167 p.Article in journal (Refereed) Published
In this work, the first example of a hierarchically structured hollow silica system is reported without any chemical modification to the enzyme involved in the process. The leaching of the physically adsorbed enzyme is substantially restrained in comparison to pure hollow silica supports. The hierarchical architecture is composed of the ordered hollow silica spheres with a shell-in-shell structure. This rationally integrated architecture, which serves as the host for glucose oxidase immobilization, displays many significant advantages, including increases in mechanical stability, enzyme loading, and bioactivity, and a decrease in enzyme leaching compared to existing pure hollow silica matrices. This facilitates further multifarious applications for enhanced enzyme immobilization, biosensors, and biocatalysis.
Place, publisher, year, edition, pages
2013. Vol. 23, no 17, 2162-2167 p.
ally structured particles; hollow silica; glucose oxidase; enzyme immobilization
IdentifiersURN: urn:nbn:se:liu:diva-87296DOI: 10.1002/adfm.201201793ISI: 000318315800009OAI: oai:DiVA.org:liu-87296DiVA: diva2:588816