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Electrochemical immunosensor with N-doped graphene-modified electrode for label-free detection of the breast cancer biomarker CA 15-3
Jiangsu University, Zhenjiang, China and University of Jinan, China.
University of Jinan, China.
Jiangsu University, Zhenjiang, China.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-1815-9699
2013 (English)In: Biosensors and Bioelectronics, ISSN 0956-5663, EISSN 1873-4235, Vol. 43, 25-29 p.Article in journal (Refereed) Published
Abstract [en]

Highly sensitive and label-free detection of the biomarker carbohydrate antigen 15-3 (CA 15-3) remains a challenge in the diagnosis of breast cancer. Here, a novel electrochemical immunosensor capable of sensitive and label-free detection of CA 15-3 is reported. This unique immunosensor, equipped with a highly conductive graphene (i.e., N-doped graphene sheets)-modified electrode, exhibited significantly increased electron transfer and high sensitivity toward CA 15-3. This novel immunosensor, with a low detection limit of 0.012U/mL, worked well over a broad linear range of 0.1-20U/mL. Unlike conventional immunosensors, which usually involve complicated label processing and time-consuming separations, the use of highly conductive graphene avoids the need for labels and is simple in nature. The strategy developed for this immunosensor provides a promising approach for clinical research and diagnostic applications.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 43, 25-29 p.
Keyword [en]
Electrochemical immunosensor; Graphene sheets; CA15-3; Label-free detection
National Category
Analytical Chemistry
URN: urn:nbn:se:liu:diva-87298DOI: 10.1016/j.bios.2012.11.037ISI: 000316525300005OAI: diva2:588820
Available from: 2013-01-16 Created: 2013-01-16 Last updated: 2013-10-04

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Turner, Anthony
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