Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
1995 (English)In: Nature, ISSN 0028-0836, Vol. 377, no 6548, 397-404 p.Article in journal (Refereed) Published
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
Place, publisher, year, edition, pages
Nature Publishing Group, 1995. Vol. 377, no 6548, 397-404 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-87485DOI: 10.1038/377397a0ISI: A1995RY19000039PubMedID: 7566114OAI: oai:DiVA.org:liu-87485DiVA: diva2:589499