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A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
University of California, San Diego, USA.
University of California, San Diego, USA.
University of California, San Diego, USA.
University of California, San Diego, USA.ORCID iD: 0000-0003-3927-4394
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1997 (English)In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 387, no 6628, 43-48 p.Article in journal (Refereed) Published
Abstract [en]

Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.

Place, publisher, year, edition, pages
Nature Publishing Group, 1997. Vol. 387, no 6628, 43-48 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-87484DOI: 10.1038/387043a0ISI: A1997WW75800041OAI: oai:DiVA.org:liu-87484DiVA: diva2:589505
Available from: 2013-01-18 Created: 2013-01-18 Last updated: 2017-12-06

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Söderström, Mats

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