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Bisphenol A exposure increases liver fat in juvenile fructose-fed Fischer 344 rats
Uppsala University, Sweden.
Uppsala University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Work and Environmental Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Occupational and Environmental Medicine Center.
Uppsala University, Sweden.
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2013 (English)In: Toxicology, ISSN 0300-483X, E-ISSN 1879-3185, Vol. 303, 125-132 p.Article in journal (Refereed) Published
Abstract [en]

Background

Prenatal exposure to bisphenol A (BPA) has been shown to induce obesity in rodents. To evaluate if exposure also later in life could induce obesity or liver damage we investigated these hypothesises in an experimental rat model.

Methods

From five to fifteen weeks of age, female Fischer 344 rats were exposed to BPA via drinking water (0.025, 0.25 or 2.5 mg BPA/L) containing 5% fructose. Two control groups were given either water or 5% fructose solution. Individual weight of the rats was determined once a week. At termination magnetic resonance imaging was used to assess adipose tissue amount and distribution, and liver fat content. After sacrifice the left perirenal fat pad and the liver were dissected and weighed. Apolipoprotein A-I in plasma was analyzed by western blot.

Results

No significant effects on body weight or the weight of the dissected fad pad were seen in rats exposed to BPA, and MRI showed no differences in total or visceral adipose tissue volumes between the groups. However, MRI showed that liver fat content was significantly higher in BPA-exposed rats than in fructose controls (p = 0.04). BPA exposure also increased the apolipoprotein A-I levels in plasma (p < 0.0001).

Conclusion

We found no evidence that BPA exposure affects fat mass in juvenile fructose-fed rats. However, the finding that BPA in combination with fructose induced fat infiltration in the liver at dosages close to the current tolerable daily intake (TDI) might be of concern given the widespread use of this compound in our environment.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 303, 125-132 p.
Keyword [en]
MRI; Liver fat; Bisphenol A; Obesity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-87627DOI: 10.1016/j.tox.2012.09.013ISI: 000314856800014OAI: oai:DiVA.org:liu-87627DiVA: diva2:589778
Available from: 2013-01-19 Created: 2013-01-19 Last updated: 2017-12-06

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Karlsson, Helen

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