liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
IL-8, IL-10, TGF-beta, and GCSF Levels Were Increased in Severe Persistent Allergic Asthma Patients with the Anti-IgE Treatment
Antalya Training and Research Hospital, Turkey .
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Toronto Hospital, University Health Network, Canada.
2012 (English)In: Mediators of Inflammation, ISSN 0962-9351, E-ISSN 1466-1861, no 720976Article in journal (Refereed) Published
Abstract [en]

Background. Allergic asthma is showed an increase in Th2-cytokine and IgE levels and an accumulation activation of Th2 cells, eosinophils and mast cells. However, recent studies focused on cell-based mechanisms for the pathogenesis of allergic asthma. Objectives. In this study, we compare the anti-IgE treatment modality in the dynamics of immune system cytokine levels in severe persistent asthma (SPA) patients who had no other any allergic disease, newly diagnosed allergic asthma patients and healthy volunteers. Study Design. The study population consisted of 14 SPA patients, 14 newly diagnosed allergic asthma patients and 14 healthy volunteers included as controls. Cytokine levels were measured. Total and specific IgE levels of anti-IgE monoclonal antibody treated patients, serum high-sensitivity C-reactive protein (hsCRP) levels, FEV1/FVC rates and asthma control test (ACT) were measured for the clinical follow-up. Results. We observed that SPA patients presented increasing levels of IL-8, IL-10, TGF-beta and GCSF during the anti-IgE treatment in period of sampling times at 4 months and 18 months. However this increase was not correlated neither with serum hsCRP levels nor FEV1/FVC rates. Conclusions. Our study gives a different perspective for the SPA and anti-IgE immunotherapy efficacy at the cell cytokine-linked step.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation , 2012. no 720976
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-87968DOI: 10.1155/2012/720976ISI: 000312847600001OAI: diva2:601025
Available from: 2013-01-28 Created: 2013-01-28 Last updated: 2013-03-22

Open Access in DiVA

fulltext(403 kB)171 downloads
File information
File name FULLTEXT01.pdfFile size 403 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Bisgin, Atil
By organisation
Department of Clinical and Experimental MedicineFaculty of Health Sciences
In the same journal
Mediators of Inflammation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 171 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 44 hits
ReferencesLink to record
Permanent link

Direct link