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Cutting edge: Natural DNA repetitive extragenic sequences from Gram-negative pathogens strongly stimulate TLR9
University of Gothenburg, Sweden.
Granada Centre Europeo Empresas and Innovac, Spain.
Instituto de Parasitologia y Biomedicina López-Neyra, Armilla, Spain.
Granada Centre Europeo Empresas and Innovac, Spain.
2007 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 179, no 1, 31-35 p.Article in journal (Refereed) Published
Abstract [en]

Bacterial DNA exerts immunostimulatory effects on mammalian cells via the intracellular TLR9. Although broad analysis of TLR9-mediated immunostimulatory potential of synthetic oligonucleotides has been developed, which kinds of natural bacterial DNA sequences are responsible for immunostimulation are not known. This work provides evidence that the natural DNA sequences named repetitive extragenic palindromic (REPs) sequences present in Gram-negative bacteria are able to produce innate immune system stimulation via TLR9. A strong induction of IFN-alpha production by REPs from Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, and Neisseria meningitidis was detected in splenocytes from 129 mice. In addition, the involvement of TLR9 in immune stimulation by REPs was confirmed using B6.129P2-Tlr9(tm1Aki) knockout mice. Considering the involvement of TLRs in Gram-negative septic shock, it is conceivable that REPs play a role in its pathogenesis. This study highlights REPs as a potential novel target in septic shock treatment.

Place, publisher, year, edition, pages
American Association of Immunologists , 2007. Vol. 179, no 1, 31-35 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-87936ISI: 000247497600006PubMedID: 17579017OAI: diva2:601140
Available from: 2013-01-28 Created: 2013-01-28 Last updated: 2013-02-12

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Magnusson, Mattias
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