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High proliferation is associated with inferior Outcome in male breast cancer patients
Vastmanland County Hospital, Sweden .
Uppsala University, Sweden .
Lund University, Sweden .
Örebro University Hospital, Sweden .
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2013 (English)In: Modern Pathology, ISSN 0893-3952, E-ISSN 1530-0285, Vol. 26, no 1, 87-94 p.Article in journal (Refereed) Published
Abstract [en]

Assessment of proliferation is important in female breast cancer and individual treatment decisions are based upon its results, especially in the lumina! subgroups. Gene expression analyses fail to group male breast cancer into the intrinsic subgroups previously established in female breast cancer. Even though proliferation has been shown to divide male breast cancer into molecular subgroups with different prognoses, the clinical importance of proliferation markers has not yet been elucidated. Previous studies in male breast cancer have demonstrated contradictory results regarding the prognostic impact of histological grade and Ki-67, parameters strongly associated with proliferation. The aim of the present project was to study proliferation in male breast cancer by assessing other proliferation-related markers viz. cyclins A, B, D1 and mitotic count. A total of 197 male breast cancer cases with accessible paraffin-embedded material and outcome data were investigated. Immunohistochemical stainings were performed on tissue microarrays. Kaplan-Meier estimates and the Cox proportional regression models were used for survival analyses with breast cancer death as the event. The subset of patients with high expression of cyclin A (hazard ratio (HR) 3.7; P=0.001) and B (HR 2.7; P=0.02) demonstrated a poorer survival. Furthermore, high mitotic count was associated with an increased risk of breast cancer death (HR 2.5; P=0.01). In contrast, cyclin D1 overexpression was predictive of better breast cancer survival (HR 0.3; P=0.001). In conclusion, high levels of cyclin A and B expression and an elevated mitotic count result in a two to threefold higher risk for breast cancer death, whereas cyclin D1 overexpression halves the risk. The clinical utility of these proliferation markers needs further elucidation. Modern Pathology (2013) 26, 87-94; doi:10.1038/modpathol.2012.145; published online 24 August 2012

Place, publisher, year, edition, pages
Nature Publishing Group , 2013. Vol. 26, no 1, 87-94 p.
Keyword [en]
breast cancer, immunohistochemistry, male
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-88461DOI: 10.1038/modpathol.2012.145ISI: 000313306900010OAI: diva2:604071

Funding Agencies|Regional Research Foundation in Uppsala-Orebro||Lions Cancer Foundation||University Hospital||Uppsala and Vastmanlands Research Foundation||

Available from: 2013-02-07 Created: 2013-02-07 Last updated: 2013-02-07

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