The effects of PTH, loading and surgical insult on cancellous bone at the bone-implant interface in the rabbit
2013 (English)In: Bone, ISSN 8756-3282, E-ISSN 1873-2763, Vol. 52, no 2, 718-724 p.Article in journal (Refereed) Published
Enhancing the quantity and quality of cancellous bone with anabolic pharmacologic agents may lead to more successful outcomes of non-cemented joint replacements. Using a novel rabbit model of cancellous bone loading, we examined two specific questions regarding bone formation at the bone-implant interface: (1) does the administration of intermittent PTH, a potent anabolic agent, and mechanical loading individually and combined enhance the pen-implant cancellous bone volume fraction; and, (2) does surgical trauma enhance the anabolic effect of PTH on pen-implant bone volume fraction. In this model, PTH enhanced pen-implant bone volume fraction by 30% in loaded bone, while mechanical loading alone increased bone volume fraction modestly (+10%). Combined mechanical loading and PTH treatment had no synergistic effect on any cancellous parameters. However, a strong combined effect was found in bone volume fraction with combined surgery and PTH treatment (+34%) compared to intact control limbs. Adaptive changes in the cancellous bone tissue included increased ultimate stress and enhanced remodeling activity. The number of proliferative osteoblasts increased as did their expression of pro-collagen 1 and PTH receptor 1, and the number of TRAP positive osteoclasts also increased. In summary, both loading and intermittent PTH treatment enhanced pen-implant bone volume, and surgery and PTH treatment had a strong combined effect This finding is of clinical importance since enhancing early osseointegration in the post-surgical period has numerous potential benefits.
Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 52, no 2, 718-724 p.
Cancellous bone, Bone adaptation, Implant, PTH, Loading, Surgery
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-88658DOI: 10.1016/j.bone.2012.05.005ISI: 000313607700026OAI: oai:DiVA.org:liu-88658DiVA: diva2:605506
Funding Agencies|Orthopaedic Research and Education Foundation||National Institutes of Health|R01-AR056802R01-AG028664P30-AR046121|2013-02-142013-02-142013-02-26