Red wine, white wine, rosé wine, and grape juice inhibit angiotensin-converting enzyme in human endothelial cells
2013 (English)In: International Journal of Nutrition, Pharmacology, Neurological Diseases, ISSN 2231-0738, EISSN 2231-2722, Vol. 3, no 1, 17-23 p.Article in journal (Refereed) Published
Background: Beneficial effects of wine on cardiovascular disease have been shown previously, but the mechanism is still unknown. The renin-angiotensin system is an important mechanism in the body concerning regulation of blood pressure, fluid, and electrolyte balance, and the angiotensin-converting enzyme (ACE) is a key enzyme in this system. Aims: The aim of this study was to investigate the effect of red wine, white wine, rosι wine, and alcohol-free grape juice on somatic ACE-1 activity. The effects of the stilbene resveratrol and its glycoside, resveratrol-3-glycoside were also tested on ACE activity and concentration of nitric oxide (NO). Materials and Methods: Cultured endothelial cells from human umbilical veins (HUVEC) were incubated with wine, grape juice, resveratrol, or resveratrol-3-glycoside. Ethanol was used as control in the corresponding concentration (13%). Results: After incubation, a significant inhibition of ACE activity was seen with all the wines tested and the red grape juice. This inhibition was of a similar magnitude except for a lesser inhibition with the rosι wine. No significant inhibition was seen with the white grape juice, resveratrol, resveratrol-3-glycoside, or ethanol alone, and neither did resveratrol nor resveratrol-3-glycoside affect the concentration of NO. Conclusions: The effect of wine and grape juice on ACE activity in HUVEC is dependent on the amount of flavonoids and not on the content of alcohol or resveratrol.
Place, publisher, year, edition, pages
Medknow Publications and Media , 2013. Vol. 3, no 1, 17-23 p.
ACE, cardiovascular disease, ethanol, grape juice, resveratrol, wine
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-89143DOI: 10.4103/2231-0738.106975OAI: oai:DiVA.org:liu-89143DiVA: diva2:607258