liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Red wine, white wine, rosé wine, and grape juice inhibit angiotensin-converting enzyme in human endothelial cells
Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
2013 (English)In: International Journal of Nutrition, Pharmacology, Neurological Diseases, ISSN 2231-0738, EISSN 2231-2722, Vol. 3, no 1, 17-23 p.Article in journal (Refereed) Published
Abstract [en]

Background: Beneficial effects of wine on cardiovascular disease have been shown previously, but the mechanism is still unknown. The renin-angiotensin system is an important mechanism in the body concerning regulation of blood pressure, fluid, and electrolyte balance, and the angiotensin-converting enzyme (ACE) is a key enzyme in this system. Aims: The aim of this study was to investigate the effect of red wine, white wine, rosι wine, and alcohol-free grape juice on somatic ACE-1 activity. The effects of the stilbene resveratrol and its glycoside, resveratrol-3-glycoside were also tested on ACE activity and concentration of nitric oxide (NO). Materials and Methods: Cultured endothelial cells from human umbilical veins (HUVEC) were incubated with wine, grape juice, resveratrol, or resveratrol-3-glycoside. Ethanol was used as control in the corresponding concentration (13%). Results: After incubation, a significant inhibition of ACE activity was seen with all the wines tested and the red grape juice. This inhibition was of a similar magnitude except for a lesser inhibition with the rosι wine. No significant inhibition was seen with the white grape juice, resveratrol, resveratrol-3-glycoside, or ethanol alone, and neither did resveratrol nor resveratrol-3-glycoside affect the concentration of NO. Conclusions: The effect of wine and grape juice on ACE activity in HUVEC is dependent on the amount of flavonoids and not on the content of alcohol or resveratrol.

Place, publisher, year, edition, pages
Medknow Publications and Media , 2013. Vol. 3, no 1, 17-23 p.
Keyword [en]
ACE, cardiovascular disease, ethanol, grape juice, resveratrol, wine
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-89143DOI: 10.4103/2231-0738.106975OAI: diva2:607258
Available from: 2013-02-22 Created: 2013-02-22 Last updated: 2013-03-04

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Persson, Ingrid
By organisation
PharmacologyFaculty of Health Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 71 hits
ReferencesLink to record
Permanent link

Direct link