liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Computer assisted evaluation of skin capillary density supports the hypothesis of microvascular shunting in erythromelalgia
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
National Hospital, Dept. of Dermatology, Oslo, Norway.
Hamlet Hospital, Copenhagen Denmark and University of Oslo, Norway.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Erythromelalgia subjects often suffer from burning pain in distal parts of the extremities, aggravated by warmth and relieved by cooling. Affected skin is hyperemic and has an increased skin temperature. The shunting hypothesis for the pathogenesis of erythromelalgia, postulates maldistribution of skin microvascular blood flow with increased thermoregulatory flow through arteriovenous shunts and an inadequate nutritive perfusion with a corresponding tissue hypoxia. Our aim was to characterize recruitment and steal distribution changes in affected skin with the aid of an enhanced technique of computer-assisted analysis of capillary beds. This method was used to determine the capillary density before and after central body heating in 14 patients with erythromelalgia and 10 controls. Symptoms were induced in 8 patients and their skin temperature became higher (p<0.05) after central body heating, but the number of visible or active capillaries in the dorsal aspect of the foot decreased significantly, as compared to asymptomatic patients and controls. Since the increased temperature should, normally induce capillary recruitment, and other studies using laser Doppler techniques have shown an increase in global skin perfusion during EM attacks, we conclude that the reduced capillary density shown in this study, is compatible with the hypothesis of blood shunting through AV anastomoses, deep in the dermis.

National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-89591OAI: oai:DiVA.org:liu-89591DiVA: diva2:608391
Available from: 2013-02-27 Created: 2013-02-27 Last updated: 2013-02-27
In thesis
1. Computer assisted video microscopy: in characterization of capillary ensembles
Open this publication in new window or tab >>Computer assisted video microscopy: in characterization of capillary ensembles
2000 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis focuses on evaluation and analysis of capillary microcirculatory changes in the skin, that can be improved and extended by computer assisted video microscopy. Capillary microscopy has been used extensively, both in clinical practice and research, to study different phenomena in the microvasculature of the skin, mainly in the nailfold of fingers and toes where a large portion of the capillary loop can be observed.

In the majority of the different skin regions, the nutritive capillary network approaches the skin surface perpendicularly and capillary microscopy in these sites reveals the apex of the capillary loop as a dark spot. The main approach in this work has been to study a large ensemble of capillary loops, in order to apply statistical and planar models whilst, at the same time, obtaining spatial parameters related to the capillary localization.

The statistical models of proximity are based on nearest neighbour methods and triangulation techniques. The main reason for introducing these models is because of their capability to characterize the heterogeneity of the capillary ensemble.

A computer assisted video microscopy system, that enables both capturing and evaluating of capillary bed images, was assembled and was, thereafter, successfully used in laboratory and clinical studies.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2000. 64 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 648
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-29442 (URN)14788 (Local ID)91-7219-822-2 (ISBN)14788 (Archive number)14788 (OAI)
Public defence
2000-09-12, Berzeliussalen, Universitetssjukhuset, Linköping, 09:00 (Swedish)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-02-27

Open Access in DiVA

No full text

Authority records BETA

Salerud, Göran

Search in DiVA

By author/editor
Salerud, Göran
By organisation
Department of Biomedical EngineeringThe Institute of Technology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 50 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf