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Radiofrequency Ablation as Initial Therapy in Paroxysm Atrial Fibrillation
Aarhus University Hospital, Denmark.
Gentofte University Hospital, Copenhagen, Denmark.
Tampere University Hospital, Finland.
Leipzig University Hospital, Germany.
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2012 (English)In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 367, no 17, 1587-1595 p.Article in journal (Refereed) Published
Abstract [en]

Background

There are limited data comparing radiofrequency catheter ablation with antiarrhythmic drug therapy as first-line treatment in patients with paroxysmal atrial fibrillation.

Methods

We randomly assigned 294 patients with paroxysmal atrial fibrillation and no history of antiarrhythmic drug use to an initial treatment strategy of either radiofrequency catheter ablation (146 patients) or therapy with class IC or class III antiarrhythmic agents (148 patients). Follow-up included 7-day Holter-monitor recording at 3, 6, 12, 18, and 24 months. Primary end points were the cumulative and per-visit burden of atrial fibrillation (i.e., percentage of time in atrial fibrillation on Holter-monitor recordings). Analyses were performed on an intention-to-treat basis.

Results

There was no significant difference between the ablation and drug-therapy groups in the cumulative burden of atrial fibrillation (90th percentile of arrhythmia burden, 13% and 19%, respectively; P=0.10) or the burden at 3, 6, 12, or 18 months. At 24 months, the burden of atrial fibrillation was significantly lower in the ablation group than in the drug-therapy group (90th percentile, 9% vs. 18%; P=0.007), and more patients in the ablation group were free from any atrial fibrillation (85% vs. 71%, P=0.004) and from symptomatic atrial fibrillation (93% vs. 84%, P=0.01). One death in the ablation group was due to a procedure-related stroke; there were three cases of cardiac tamponade in the ablation group. In the drug-therapy group, 54 patients (36%) underwent supplementary ablation.

Conclusions

In comparing radiofrequency ablation with antiarrhythmic drug therapy as first-line treatment in patients with paroxysmal atrial fibrillation, we found no significant difference between the treatment groups in the cumulative burden of atrial fibrillation over a period of 2 years.

Place, publisher, year, edition, pages
Massachusetts Medical Society , 2012. Vol. 367, no 17, 1587-1595 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-89595DOI: 10.1056/NEJMoa1113566ISI: 000310131700005OAI: oai:DiVA.org:liu-89595DiVA: diva2:608439
Note

Funding Agencies|Danish Heart Foundation|05-4-B284-A466-22237|Biosense Webster||Finnish Foundation for Cardiovascular Research||Biotronik||Medtronic||St. Jude Medical||

Available from: 2013-02-27 Created: 2013-02-27 Last updated: 2017-12-06

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Walfridsson, Håkan

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