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Cholinergic modulation of synaptic properties of cortical layer VI input to posteromedial thalamic nucleus of the rat investigated in vitro
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
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2012 (English)In: Acta Neurobiologiae Experimentalis, ISSN 0065-1400, E-ISSN 1689-0035, Vol. 72, no 4, 461-467 p.Article in journal (Refereed) Published
Abstract [en]

The second order somatosensory thalamic nucleus (posteromedial nucleus, PoM) receives excitatory projection from layer VI of somatosensory cortex. While it is known that layer VI cortical input to first order, ventrobasal nucleus (VB) is modulated by cholinergic projections from the brainstem, no such data exists concerning the PoM nucleus. In order to study if layer VI corticothalamic transmission to PoM is also modulated we used patch-clamp recording in thalamocortical slices from the rat's brain. Excitatory postsynaptic potentials (EPSPs) were evoked in PoM cells by trains of 5 electrical pulses at 20 Hz frequency applied to corticothalamic fibers. After carbachol was applied to mimic activation of the cholinergic neuromodulatory system corticothalamic EPSP amplitudes were reduced, while facilitation of EPSP amplitudes was enhanced for each next pulse in the series. Such cholinergic control of layer VI corticothalamic synapses in PoM may be used as gain modulator for the transfer of the peripheral sensory information to the cortex.

Place, publisher, year, edition, pages
2012. Vol. 72, no 4, 461-467 p.
Keyword [en]
posteromedial thalamic nucleus, corticothalamic input, cholinergic modulation, synaptic facilitation
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-89729ISI: 000314738500013PubMedID: 23377275OAI: oai:DiVA.org:liu-89729DiVA: diva2:609248
Note

Funding Agencies|European Union European Regional Development Fund through the Foundation for Polish Science||

Available from: 2013-03-04 Created: 2013-03-04 Last updated: 2017-12-06

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Nersisyan, SyuneGranseth, Björn

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