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The potential of dual-energy computed tomography for quantitative decomposition of soft tissues to water, protein and lipid in brachytherapy
Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-1257-2383
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-9072-2204
Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-0209-498X
2013 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 58, no 4, 771-785 p.Article in journal (Refereed) Published
Abstract [en]

Dosimetric accuracy of radiation treatment planning in brachytherapy depends on knowledge of tissue composition. It has been speculated that soft tissues can be decomposed to water, lipid and protein. The aim of our work is to evaluate the accuracy of such tissue decomposition. Selected abdominal soft tissues, whose average elemental compositions were taken from literature, were decomposed using dual energy computed tomography to water, lipid and protein via the three-material decomposition method. The quality of the decomposition was assessed using relative differences between (i) mass energy absorption and (ii) mass energy attenuation coefficients of the analyzed and approximated tissues. It was found that the relative differences were less than 2% for photon energies larger than 10 keV. The differences were notably smaller than the ones for water as the transport and dose scoring medium. The choice of the water, protein and lipid triplet resulted in negative elemental mass fractions for some analyzed tissues. As negative elemental mass fractions cannot be used in general purpose particle transport computer codes using the Monte Carlo method, other triplets should be used for the decomposition. These triplets may further improve the accuracy of the approximation as the differences were mainly caused by the lack of high-Z materials in the water, protein and lipid triplet.

Place, publisher, year, edition, pages
Institute of Physics , 2013. Vol. 58, no 4, 771-785 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-89734DOI: 10.1088/0031-9155/58/4/771ISI: 000314396800004OAI: diva2:609387

Funding Agencies|Swedish Cancer Society (Cancerfonden)|100 512|

Available from: 2013-03-05 Created: 2013-03-05 Last updated: 2015-03-20

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Malusek, AlexandrKarlsson, MattiasMagnusson, MariaAlm Carlsson, Gudrun
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Radiation PhysicsFaculty of Health SciencesDivision of Radiological SciencesComputer VisionThe Institute of TechnologyDepartment of Radiation Physics
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