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On the biological basis for competing macroscopic dose descriptors for kilovoltage dosimetry: cellular dosimetry for brachytherapy and diagnostic radiology
Carleton University, Canada .
Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics UHL.
Virginia Commonwealth University, VA USA .
2013 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 58, no 4, 1123-1150 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this work is to investigate how alternative macroscopic dose descriptors track absorbed dose to biologically relevant subcellular targets via Monte Carlo (MC) analysis of cellular models for a variety of cancerous and normal soft tissues for kilovoltage radiation. The relative mass distributions of water, light inorganic elements, and protein components of nuclear and cytoplasm compartments for various tissues are determined from a literature review. These data are used to develop representative cell models to demonstrate the range of mass elemental compositions of these subcellular structures encountered in the literature from which radiological quantities (energy absorption and attenuation coefficients; stopping powers) are computed. Using representative models of cell clusters, doses to subcellular targets are computed using MC simulation for photon sources of energies between 20 and 370 keV and are compared to bulk medium dose descriptors. It is found that cells contain significant and varying mass fractions of protein and inorganic elements, leading to variations in mass energy absorption coefficients for cytoplasm and nuclear media as large as 10% compared to water for sub-50 keV photons. Doses to subcellular structures vary by as much as 23% compared to doses to the corresponding average bulk medium or to small water cavities embedded in the bulk medium. Relationships between cellular target doses and doses to the bulk medium or to a small water cavity embedded in the bulk medium are sensitive to source energy and cell morphology, particularly for lower energy sources, e. g., low energy brachytherapy (andlt;50 keV). Results suggest that cells in cancerous and normal soft tissues are generally not radiologically equivalent to either water or the corresponding average bulk tissue. For kilovoltage photon sources, neither dose to bulk medium nor dose to water quantitatively tracks energy imparted to biologically relevant subcellular targets for the range of cellular morphologies and tissues considered.

Place, publisher, year, edition, pages
Institute of Physics , 2013. Vol. 58, no 4, 1123-1150 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-89735DOI: 10.1088/0031-9155/58/4/1123ISI: 000314396800025OAI: diva2:609389

Funding Agencies|Natural Sciences and Engineering Research Council of Canada||Carleton University Research Office||Canadian Foundation for Innovation||US National Institutes of Health|P01 CA 602116|Swedish Cancer Society (Cancerfonden)|100512|

Available from: 2013-03-05 Created: 2013-03-05 Last updated: 2013-03-05

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Carlsson Tedgren, Åsa
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Radiation PhysicsFaculty of Health SciencesDepartment of Radiation Physics UHL
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