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Maternal drug use during pregnancy and asthma risk among children
Lund University, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
Karolinska Institute, Sweden .
National Board Health and Welf, Sweden .
2013 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 24, no 1, 28-32 p.Article in journal (Refereed) Published
Abstract [en]

Background Maternal use of some drugs, notably paracetamol and drugs for gastroesophageal reflux, has been associated with an increased risk of childhood asthma in the child. We wanted to analyze these associations with consideration to the confounding of maternal asthma. Methods Childhood asthma was identified from the Swedish National Prescription Register and maternal drug use during the latter part of pregnancy from antenatal records, computerized in the Swedish Medical Birth Register. Risks were estimated as odds ratios (OR) with 95% confidence intervals, using MantelHaenszel technique with adjustment for year of birth, maternal age, parity, smoking habits, and BMI. Results A statistical association between maternal use of many different drugs, including paracetamol, and childhood asthma existed but was mainly due to concomitant drug use, related to maternal asthma. The only associations that appeared to be true were with drugs for gastroesophageal reflux (adjusted (OR) = 1.32, 95% CI, 1.181.54) and with opiates (adjusted OR = 1.56 (96% CI, 1.052.34). Conclusions Maternal use of paracetamol did not seem to increase the risk of childhood asthma, but the previously described association with drugs for gastroesophageal reflux was supported. The analysis is complicated by the confounding from maternal asthma.

Place, publisher, year, edition, pages
John Wiley and Sons , 2013. Vol. 24, no 1, 28-32 p.
Keyword [en]
childhood asthma, drug use in pregnancy, opioids, paracetamol
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-89737DOI: 10.1111/pai.12034ISI: 000313892300006OAI: diva2:609391

Funding Agencies|Evy and Gunnar Sandberg Foundation, Lund, Sweden||

Available from: 2013-03-05 Created: 2013-03-05 Last updated: 2013-03-05

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Finnström, Orvar
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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
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