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Increased Prevalence of Antibodies Against Dietary Proteins in Children and Young Adults With Cerebral Palsy
Örebro University Hospital, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Örebro University Hospital, Sweden .
Clin Research Centre, Sweden .
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2013 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 56, no 2, 233-238 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: Undernourishment is common in children with cerebral palsy (CP), but the reasons are unknown. We previously reported elevated levels of immunoglobulin (Ig) A and IgG antibodies against gliadin (AGA) and tissue transglutaminase (tTG) in 99 children and young adults with CP without characteristic findings of gluten enteropathy in small bowel biopsies. Our aim was to perform a case-control study of IgG antibodies against other dietary antigens, AGA, anti-tTG, and IgE antibodies against wheat and gluten. less thanbrgreater than less thanbrgreater thanMethods: Sera from 99 cases with CP and 99 healthy, age-and sex-matched controls were analysed with fluorescence enzyme-linked immunosorbent assay for detection of IgG antibodies against beta-lactoglobulin, casein, egg white, IgG-and IgA-AGA, IgA-anti-tTG, and IgE antibodies against gluten and wheat. less thanbrgreater than less thanbrgreater thanResults: Compared with controls, the odds ratio in cases with CP for having elevated levels of IgG antibodies against beta-lactoglobulin was 17.0 (95% confidence interval [CI] 2.3-128), against casein 11.0 (95% CI 2.6-46.8), and against egg white 7.0 (95% CI 1.6-30.8). The IgE responses for wheat/gluten were generally low. The tetraplegic and dyskinetic CP subtypes had significantly higher frequencies of elevated levels for all of the tested antibodies except IgG against egg white, and IgA-anti-tTG. A significantly lower weight was seen in cases with CP with positive versus negative serology. less thanbrgreater than less thanbrgreater thanConclusions: Elevated levels of IgG against dietary antigens were more frequent in the CP group compared with controls, and particularly in the tetraplegic and dyskinetic CP subtypes with the most severe neurologic handicap and undernourishment. Hypothetically, malnourishment may cause increased intestinal permeability and thus immunization against dietary antigens.

Place, publisher, year, edition, pages
Lippincott, Williams and Wilkins , 2013. Vol. 56, no 2, 233-238 p.
Keyword [en]
cerebral palsy, children, dietary antibodies, gluten sensitivity
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-89740DOI: 10.1097/MPG.0b013e318272cbf4ISI: 000314099600031OAI: diva2:609392

Funding Agencies|Research Committee of Orebro County Council||Folke Bernadotte Foundation, Stockholm, Sweden||

Available from: 2013-03-05 Created: 2013-03-05 Last updated: 2014-03-21

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Dahle, Charlotte
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Clinical ImmunologyFaculty of Health SciencesDepartment of Clinical Immunology and Transfusion Medicine
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