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Cardiovascular function in adulthood following intrauterine growth restriction with abnormal fetal blood flow
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences.
Lund University, Sweden .
Lund University, Sweden .
Linköping University, Department of Medical and Health Sciences, Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.
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2013 (English)In: Ultrasound in Obstetrics and Gynecology, ISSN 0960-7692, E-ISSN 1469-0705, Vol. 41, no 2, 177-184 p.Article in journal (Refereed) Published
Abstract [en]

Objectives To examine whether intrauterine growth restriction (IUGR) is associated with increased cardiovascular risk later in life. Methods We examined 19 young adults (aged 2225 years) who were born at term after IUGR, along with 18 controls. All had been examined previously with fetal Doppler, and in the present follow-up with echocardiography, carotid echo-tracking ultrasound, applanation tonometry, blood pressure and laser Doppler, in order to characterize their cardiac and vascular geometry and/or function. Results The diameter of the ascending aorta and the left ventricular diameter were smaller in the IUGR group, but only ascending aortic diameter remained significantly smaller after adjustment for body surface area (Pandlt;0.05). The aortic pressure augmentation index was higher in the IUGR group (Pandlt;0.05). The common carotid artery diameter, intimamedia thickness and distensibility as well as left ventricular mass and function were similar in the two groups. IUGR status was found to be an independent predictor of ascending aortic diameter. Conclusions IUGR due to placental dysfunction seems to contribute to the higher systolic blood pressure augmentation and the smaller aortic dimensions that are observed in adults more than 20 years later, with possible negative consequences for future left ventricular performance due to increased aortic impedance.

Place, publisher, year, edition, pages
Wiley-Blackwell , 2013. Vol. 41, no 2, 177-184 p.
Keyword [en]
aorta, echocardiography, intrauterine growth restriction, pulse wave analysis, young adulthood
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-89805DOI: 10.1002/uog.12314ISI: 000314473600011OAI: diva2:609790
Available from: 2013-03-07 Created: 2013-03-07 Last updated: 2014-08-21

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Bjarnegård, NiclasLänne, Toste
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Division of Cardiovascular MedicineFaculty of Health SciencesPhysiologyDepartment of Thoracic and Vascular Surgery
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