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IgA antibodies against tissue transglutaminase, endomysium and gliadin in idiopathic polyneuropathy
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Ryhov County Hospital, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Occupational and Environmental Medicine Center.
University of Gothenburg, Sweden .
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2013 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 127, no 2, 109-115 p.Article in journal (Refereed) Published
Abstract [en]

Objectives To study the prevalence of antibodies of IgA class against tissue transglutaminase (tTG), endomysium (EMA) and gliadin (AGA) in patients with chronic idiopathic axonal polyneuropathy (CIAP) and to characterize the patients clinically and neurophysiologically. Methods Of 182 patients, 126 patients agreed to blood sampling. Sera were analysed by ELISAs detecting anti-tTG and AGA, whereas EMA was analysed by indirect immunofluorescence (IF) microscopy. Gastrointestinal symptoms were assessed by data from medical records and patient interviews. Results Nine of 126 patients (7%) were seropositive in at least one test (five with positive anti-tTG and/or EMA and four with positive AGA only). One patient with elevated levels of all specificities had laboratory signs of malabsorption and gastrointestinal complaints with abdominal pain and diarrhoea. Conclusions Elevated levels of IgA-AGA were slightly more frequent in patients with CIAP (4%) compared to 2.5% in 1866 healthy blood donors. Highly specific serological markers indicative of coeliac disease (CD) (anti-tTG and EMA) were somewhat more common in our patients with CIAP (4%) than expected from normal reference values and from studies of the prevalence of CD in the general population. Even though these findings may indicate a relationship, the aetiological importance is unclear.

Place, publisher, year, edition, pages
John Wiley and Sons , 2013. Vol. 127, no 2, 109-115 p.
Keyword [en]
neuropathy, idiopathic, gluten sensitivity, coeliac disease, anti-tissue transglutaminase, anti-gliadin, anti-endomysium
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-89742DOI: 10.1111/j.1600-0404.2012.01687.xISI: 000313886700007OAI: diva2:609800

Funding Agencies|Swedish Council for Work Life and Social Research||Medical Research Council of Southeast Sweden (FORSS)||

Available from: 2013-03-07 Created: 2013-03-05 Last updated: 2014-03-20

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Vrethem, MagnusTondel, MartinDahle, Charlotte
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NeurologyFaculty of Health SciencesDepartment of NeurologyOccupational and Environmental MedicineOccupational and Environmental Medicine CenterClinical ImmunologyDepartment of Clinical Immunology and Transfusion Medicine
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Acta Neurologica Scandinavica
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