Visual assessment of biliary excretion of Gd-EOB-DTPA in patients with suspected diffuse liver disease – a biopsy-controlled prospective study
2015 (English)In: European Journal of Radiology Open, ISSN 2352-0477, Vol. 2, 19-25 p.Article in journal (Refereed) Published
Objectives: To qualitatively evaluate late dynamic contrast phases, 10, 20 and 30 min, after administration of Gd-EOB-DTPA with regard to biliary excretion in patients presenting with elevated liver enzymes without any clinical signs of cirrhosis or hepatic decompensation and to compare the visual assessment of contrast agent excretion with histo-pathological fibrosis stage, contrast uptake parameters and blood tests.
Methods: 29 patients were prospectively examined using 1.5-T MRI. The visually assessed presence (1) or absence (0) of contrast agent for each of five anatomical regions in randomly reviewed time-series was summarised on a four grade scale. The scores, including a total visual score, were related to the histo-pathological findings, the quantitative contrast agent uptake parameters and blood tests
Results: No relationship between the fibrosis grade or contrast uptake parameters expressed as KHep or LSC_N could be established. A negative correlation between the visual assessment and ALP was found. Comparing a sub-group of cholestatic patients with fibrosis score and Gd-EOB-DTPAdynamic parameters did not add any additional significant correlation.
Conclusions: In this prospective study with a limited number of patients we were not able to demonstrate a correlation between visually assessed biliary excretion of Gd-EOB-DTPA and histo-pathological or contrast uptake parameters.
Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 2, 19-25 p.
Gd-EOB-DTPA, Dynamic contrast enhanced MRI, Liver, Bile, Excretion
Radiology, Nuclear Medicine and Medical Imaging Physical Chemistry
IdentifiersURN: urn:nbn:se:liu:diva-90159DOI: 10.1016/j.ejro.2014.12.004OAI: oai:DiVA.org:liu-90159DiVA: diva2:612230