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Combined use of selective serotonin reuptake inhibitors and sedatives/hypnotics during pregnancy: risk of relatively severe congenital malformations or cardiac defects. A register study
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Drug Research.ORCID iD: 0000-0002-6041-0744
Lund University, Sweden .
2013 (English)In: BMJ Open, ISSN 2044-6055, Vol. 3, no 2Article in journal (Refereed) Published
Abstract [en]

Objectives To investigate the proposed synergistic teratogenic effect of use of selective serotonin receptor inhibitors (SSRI) together with sedatives or hypnotics, primarily benzodiazepines, during pregnancy.

Design Cohort study of congenital malformations after maternal use of SSRI, sedatives/hypnotics or the combination of the two drug categories.

Setting Swedish national health registers.

Participants A total of 10 511 infants born of women who had used SSRI drugs but no other central nervous system (CNS)-active drug, 1000 infants born of women who had used benzodiazepines and no other CNS-active drug, and 406 infants whose mothers had used both SSRI and benzodiazepines but no other CNS-active drug.

Results None of the three groups showed a higher risk for any relatively severe congenital malformation or any cardiac defect when comparison was made with the general population risk (adjusted risk ratio (RR) for the combination of SSRI and benzodiazepines and a relatively severe malformation=1.17 (95% CI 0.70 to 1.73). Similar results were obtained for the combination of SSRI with other sedative/hypnotic drugs.

Conclusions The previously stated increased risk associated with the combined use of these drug categories, notably for a cardiac defect, could not be replicated.

Place, publisher, year, edition, pages
BMJ Publishing Group: BMJ Open / BMJ Journals , 2013. Vol. 3, no 2
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-90213DOI: 10.1136/bmjopen-2012-002166ISI: 000315087200024OAI: diva2:612338

Funding Agencies|Evy and Gunnar Sandbergs Foundation, Lund||Swedish Medical Research Council|2009-4740|

Available from: 2013-03-21 Created: 2013-03-21 Last updated: 2014-03-26

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Reis, Margareta
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