Anti-GBM disease with a mild relapsing course and low levels ofanti-GBM autoantibodies
2012 (English)In: Clinical Kidney Journal, ISSN 2048-8505, E-ISSN 2048-8513, Vol. 5, no 6, 549-551 p.Article in journal (Refereed) Published
Anti-glomerular basement membrane disease (anti-GBM) is usually characterized by rapidly progressive glomerulonephritis, and when autoantibody production has ceased, relapses are rare. Here, we report a 71-year-old women diagnosed at a stage of mild renal insufficiency. Over a period of 10 years, she experienced three mild relapses with return of anti-GBM antibodies, haematuria and slight elevations in serum creatinine level. All three relapses responded to immunosuppressive therapy, and all were preceded by peaks of myeloperoxidase-antineutrophil cytoplasm antibodies (MPO-ANCA). This case shows that long-term follow-up is warranted in patients treated for anti-GBM-mediated disease, but urinary dipsticks may be sufficient for early detection of relapses.
Place, publisher, year, edition, pages
Oxford University Press, 2012. Vol. 5, no 6, 549-551 p.
anti-GBM; glomerulonephritis; Goodpasture’s disease; relapses
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-90222DOI: 10.1093/ckj/sfs098OAI: oai:DiVA.org:liu-90222DiVA: diva2:612362