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Anti-GBM disease with a mild relapsing course and low levels ofanti-GBM autoantibodies
Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
Department of Medicine, NÄL Hospital, Trollhättan, Sweden.
Eurodiagnostica AB, Malmö, Sweden.
2012 (English)In: Clinical Kidney Journal, ISSN 2048-8505, E-ISSN 2048-8513, Vol. 5, no 6, 549-551 p.Article in journal (Refereed) Published
Abstract [en]

Anti-glomerular basement membrane disease (anti-GBM) is usually characterized by rapidly progressive glomerulonephritis, and when autoantibody production has ceased, relapses are rare. Here, we report a 71-year-old women diagnosed at a stage of mild renal insufficiency. Over a period of 10 years, she experienced three mild relapses with return of anti-GBM antibodies, haematuria and slight elevations in serum creatinine level. All three relapses responded to immunosuppressive therapy, and all were preceded by peaks of myeloperoxidase-antineutrophil cytoplasm antibodies (MPO-ANCA). This case shows that long-term follow-up is warranted in patients treated for anti-GBM-mediated disease, but urinary dipsticks may be sufficient for early detection of relapses.

Place, publisher, year, edition, pages
Oxford University Press, 2012. Vol. 5, no 6, 549-551 p.
Keyword [en]
anti-GBM; glomerulonephritis; Goodpasture’s disease; relapses
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-90222DOI: 10.1093/ckj/sfs098OAI: diva2:612362
Available from: 2013-03-21 Created: 2013-03-21 Last updated: 2015-11-03Bibliographically approved

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Segelmark, Mårten
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PharmacologyFaculty of Health SciencesDepartment of Nephrology
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