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Longitudinal interferon-β effects in multiple sclerosis: differential regulation of IL-10 and IL-17A, while no sustained effects on IFN-γ, IL-4 or IL-13
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-3993-9985
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
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2013 (English)In: Journal of the Neurological Sciences, ISSN 0022-510X, E-ISSN 1878-5883, Vol. 325, no 1-2, 79-85 p.Article in journal (Refereed) Published
Abstract [en]

Background:

Recent studies in experimental models and in vitro indicate lowering of IL-17/Th17 as an important mechanism of interferon-beta (IFN-β) treatment in multiple sclerosis (MS).

Material and methods:

In this longitudinal study of MS patients (n = 25), spontaneous and myelin antigen-induced secretion of IL-4, IFN-γ and IL-10 (ELISPOT), mitogen stimulated secretion of IL-13 and IL-17A (ELISA) and circulating cytokine levels (Luminex) were recorded at inclusion and after 1.5, 3, 6 and 12 months of IFN-β treatment.

Results:

Early changes were noted for IL-4, while after one year of treatment the only recorded significant effects were a decrease in secreted IL-17A levels and an increase in IL-10 secreting cells. While IL-17A levels tended to be higher in non-responders (n = 8), the decrease in IL-17A levels seemed to be more pronounced in responders (n = 17) showing significantly lower IL-17A levels after one year as compared with non-responders.

Conclusion:

IFN-β treatment seems to mainly affect IL-17/IL-10-associated pathways rather than the IFN-γ/IL-4 axis.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 325, no 1-2, 79-85 p.
Keyword [en]
Multiple sclerosis, Interferon-beta, Cytokines, IL-4, IL-17, IL-10, Responder
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-90199DOI: 10.1016/j.jns.2012.12.001ISI: 000315323000016OAI: oai:DiVA.org:liu-90199DiVA: diva2:612363
Note

Funding Agencies|Biogen Idec||Network for Inflammation research||Swedish Foundation for Strategic Research||Swedish Association of Neurologically Disabled||County Council of Ostergotland||University Hospital of Linkoping and Lions Ostergotland||

Available from: 2013-04-03 Created: 2013-03-21 Last updated: 2017-12-06Bibliographically approved

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Kvarnström, MariaEkerfelt, ChristinaVrethem, MagnusErnerudh, Jan

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