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Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin
University of Dusseldorf, Germany .
University of Dusseldorf, Germany .
University of Copenhagen, Denmark .
University of Childrens Hospital, Slovenia .
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2013 (English)In: Diabetes/Metabolism Research Reviews, ISSN 1520-7552, E-ISSN 1520-7560, Vol. 29, no 2, 166-170 p.Article in journal (Refereed) Published
Abstract [en]

Background We investigated the adipokines adiponectin, leptin and resistin as serum biomarkers of beta-cell function in patients with type 1 diabetes. Methods One hundred and eighteen patients with type 1 diabetes (20.3 +/- 7.5years) diagnosed andlt;5years underwent standardized mixed meal test (MMTT) for 2h. Systemic concentrations of C-peptide, adiponectin, leptin and resistin obtained during MMTT were measured and compared between patient groups by multiple regression analysis. Results Patients were divided by their adipokine levels in subgroups above or below the median level (high versus low). High adiponectin levels (andgt;10.6 mu g/mL) were associated with lower C-peptide compared to the low adiponectin subgroup (pandlt;0.03). Increased leptin or resistin concentrations associated positively with beta-cell function even after adjustment for metabolic confounders (pandlt;0.04). The described associations between adipokines and C-peptide concentrations persisted in Spearman correlation tests (pandlt;0.05). Serum adipokines fell during MMTT (pandlt;0.05). Conclusions Serum adipokine levels differentially correlate with beta-cell function in type 1 diabetes independent of BMI or metabolic control. Serum adipokines should be investigated as biomarkers of beta-cell function in prospective studies and intervention trials in type 1 diabetes.

Place, publisher, year, edition, pages
John Wiley and Sons , 2013. Vol. 29, no 2, 166-170 p.
Keyword [en]
adipokine, adiponectin, C-peptide, leptin, resistin, type 1 diabetes
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-90075DOI: 10.1002/dmrr.2378ISI: 000314660400010OAI: diva2:612424

Funding Agencies|European Association for the Study of Diabetes (EFSD)||German Diabetes Association (DDG)||Deutsches Zentrum fur Diabetesforschung (DZD) e.V.||

Available from: 2013-03-21 Created: 2013-03-19 Last updated: 2013-03-21

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Ludvigsson, Johnny
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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
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