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Increased linoleic acid/alpha-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
2013 (English)In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 52, no 2, 659-665 p.Article in journal (Refereed) Published
Abstract [en]

Cord serum (CS) phospholipid fatty acid composition is associated with maternal diet during foetal life, and maternal intake of linoleic acid (LA, C18:2 omega-6) and alpha-linolenic acid (LNA, C18:3 omega-3) has been shown to influence the LA and LNA levels in CS. A possible connection between the increased incidence of atopic diseases and increased intake of LA and decreased intake of LNA in the Western world has been proposed. less thanbrgreater than less thanbrgreater thanThe aim of this study was to explore phospholipid fatty acid proportions and total IgE levels in CS from Swedish children, collected from 1985 to 2005, a period with increasing frequency of allergic diseases in Sweden, and reveal possible changes over time. less thanbrgreater than less thanbrgreater thanPhospholipid fatty acids and total IgE antibodies were analysed with gas chromatography and UniCAP(A (R)) technology, respectively, in 300 CS samples. less thanbrgreater than less thanbrgreater thanThe proportions of LA and LNA decreased significantly from 1985 to 2005 (p andlt; 0.001 for both). However, the LA/LNA ratio did increase (p andlt; 0.001), revealing a relatively larger decrease in LNA than in LA. No correlations were found between omega-6 and omega-3 fatty acids and total IgE antibodies in CS from newborn children. less thanbrgreater than less thanbrgreater thanThe LA/LNA ratio increased (p andlt; 0.001) in cord serum samples collected between 1985 and 2005, and no correlations between fatty acids and total IgE were found.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2013. Vol. 52, no 2, 659-665 p.
Keyword [en]
Cord blood, Fatty acids, Immunoglobulin E
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-90066DOI: 10.1007/s00394-012-0369-6ISI: 000314970600023OAI: oai:DiVA.org:liu-90066DiVA: diva2:612441
Note

Funding Agencies|Swedish Nutrition Foundation (SNF)||

Available from: 2013-03-21 Created: 2013-03-19 Last updated: 2017-12-06

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Warstedt, KristinaDuchén, Karel

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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
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