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Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients – A 31P-MRS study
Linköping University, Department of Medical and Health Sciences, Rehabilitation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-4630-6550
Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Rheumatology.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
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2013 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 17, no 8, 1205-1215 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND METHODS:

Fibromyalgia (FMS) has a prevalence of approximately 2% in the population. Central alterations have been described in FMS, but there is not consensus with respect to the role of peripheral factors for the maintenance of FMS. 31P magnetic resonance spectroscopy (31P-MRS) has been used to investigate the metabolism of phosphagens in muscles of FMS patients, but the results in the literature are not in consensus. The aim was to investigate the quantitative content of phosphagens and pH in resting quadriceps muscle of patients with FMS (n = 19) and in healthy controls (Controls; n = 14) using (31) P-MRS. It was also investigated whether the concentrations of these substances correlated with measures of pain and/or physical capacity.

RESULTS:

Significantly lower concentrations of adenosine triphosphate (ATP) and phosphocreatinine (PCr; 28-29% lower) were found in FMS. No significant group differences existed with respect to inorganic phosphate (Pi), Pi/PCr and pH. The quadriceps muscle fat content was significantly higher in FMS than in Controls [FMS: 9.0 ± 0.5% vs. Controls: 6.6 ± 0.6%; (mean ± standard error); P = 0.005]. FMS had significantly lower hand and leg capacity according to specific physical test, but there were no group differences in body mass index, subjective activity level and in aerobic fitness. In FMS, the specific physical capacity in the leg and the hand correlated positively with the concentrations of ATP and PCr; no significant correlations were found with pain intensities.

CONCLUSIONS:

Alterations in intramuscular ATP, PCr and fat content in FMS probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.

Place, publisher, year, edition, pages
John Wiley & Sons, 2013. Vol. 17, no 8, 1205-1215 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-90364DOI: 10.1002/j.1532-2149.2013.00284.xISI: 000322723600012PubMedID: 23364928OAI: oai:DiVA.org:liu-90364DiVA: diva2:612851
Available from: 2013-03-25 Created: 2013-03-25 Last updated: 2017-12-06Bibliographically approved

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Gerdle, BjörnForsgren, MikaelBengtsson, AnnDahlqvist Leinhard, OlofKarlsson, AnetteBrandejsky, VaslavLund, EvaLundberg, Peter

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Gerdle, BjörnForsgren, MikaelBengtsson, AnnDahlqvist Leinhard, OlofKarlsson, AnetteBrandejsky, VaslavLund, EvaLundberg, Peter
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Rehabilitation MedicineFaculty of Health SciencesPain and Rehabilitation CenterCenter for Medical Image Science and Visualization (CMIV)Radiation PhysicsDepartment of Radiation PhysicsRheumatologyDepartment of RheumatologyBiomedical InstrumentationDivision of Radiological SciencesDepartment of Radiology in Linköping
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