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Relationship Between Laser Doppler Signals and Anatomy During Deep Brain Stimulation Electrode Implantation Toward the Ventral Intermediate Nucleus and Subthalamic Nucleus
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. (MINT)ORCID iD: 0000-0002-0012-7867
Linköping University, Department of Clinical and Experimental Medicine, Neurosurgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
Linköping University, Department of Clinical and Experimental Medicine, Neurosurgery. Linköping University, Faculty of Health Sciences. (MINT)
University of Applied Sciences Northwestern Switzerland, Institute for Medical and Analytical Technologies, Muttenz, Switzerland..
2013 (English)In: Neurosurgery, ISSN 0148-396X, E-ISSN 1524-4040, Vol. 72, no 2, 127-140 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Deep brain stimulation (DBS) requires precise and safe navigation to the chosen target. Optical measurements allow monitoring of gray-white tissue boundaries (total light intensity [TLI]) and microvascular blood flow during stereotactic procedures.

OBJECTIVE: To establish the link between TLI/blood flow and anatomy along trajectories toward the ventral intermediate nucleus (Vim) and subthalamic nucleus (STN).

METHODS: Stereotactic laser Doppler measurements were obtained with millimeter precision from the cortex toward the Vim (n = 13) and STN (n = 9). Optical trajectories of TLI and blood flow were created and compared with anatomy by superimposing the Schaltenbrandt-Wahren atlas on the patients' pre- and postoperative images. Measurements were divided into anatomic subgroups and compared statistically.

RESULTS: Typical TLI trajectories with well-defined anatomic regions could be identified for the Vim and STN. TLI was significantly lower (P < .001) and microvascular blood flow significantly higher (P = .01) in the Vim targets. Of 1285 sites, 38 showed blood flow peaks, 27 of them along the Vim trajectories. High blood flow was more common close to the sulci and in the vicinity of the caudate/putamen. Along 1 Vim trajectory, a slight bleeding was suspected during insertion of the probe and confirmed with postoperative computed tomography.

CONCLUSION: Laser Doppler is useful for intraoperative guidance during DBS implantation because simultaneous measurement of tissue grayness and microvascular blood flow can be done along the trajectory with millimeter precision. Typical but different TLI trajectories were found for the Vim and STN.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2013. Vol. 72, no 2, 127-140 p.
Keyword [en]
deep brain stimulation (DBS), laser Doppler perfusion monitoring (LDPM), microvascular blood flow, optical navigation, brain atlas
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-90470DOI: 10.1227/NEU.0b013e31827e5821ISI: 000319535100005PubMedID: 23190636OAI: oai:DiVA.org:liu-90470DiVA: diva2:613465
Available from: 2013-03-28 Created: 2013-03-28 Last updated: 2017-12-06Bibliographically approved

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Wårdell, KarinZsigmond, PeterRichter, Johan

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