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Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB
Russian Academy of Sciences, St. Petersburg, Russia.
Russian Academy of Sciences, St. Petersburg, Russia.
Russian Academy of Sciences, St. Petersburg, Russia.
Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
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2013 (English)In: OncoTarget, ISSN 1949-2553, Vol. 4, no 2, 362-372 p.Article in journal (Refereed) Published
Abstract [en]

ACTN4 is an actin-binding protein that participates in cytoskeleton organisation. It resides both in the cytoplasm and nucleus and physically associates with various transcription factors. Here, we describe an effect of ACTN4 expression on transcriptional activity of the RelA/p65 subunit of NF-kB. We demonstrate that ACTN4 enhances RelA/p65-dependant expression of c-fos, MMP-3 and MMP-1 genes, but it does not affect TNC, ICAM1 and FN1 expression. Importantly, actin-binding domains of ACTN4 are not critical for the nuclear translocation and co-activation of RelA/p65-dependent transcription. Collectively, our data suggest that in the nucleus, ACTN4 functions as a selective transcriptional co-activator of RelA/p65.

Place, publisher, year, edition, pages
Impact Journals LLC , 2013. Vol. 4, no 2, 362-372 p.
Keyword [en]
TN4; RelA/p65; transcription regulation; MMP
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-90661ISI: 000318782500021OAI: diva2:614087

Funding Agencies|FEBS Collaborative Experimental Scholarship for Central and Eastern Europe||RFBR|12-04-32194 mol_a10-04-0017412-04-32252 mol_a|Russian Government Programme for the Recruitment of the leading scientists into the Russian Institutions of Higher Education|11.G34.31.0069|Federal Target Program - Scientific and Pedagogical staff of innovative Russia|Pi174|Federal Programme for Scientific training in Innovative Russia|8280|

Available from: 2013-04-03 Created: 2013-04-03 Last updated: 2013-08-01Bibliographically approved

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