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Prevalence of Childhood Celiac Disease and Changes in Infant Feeding
Umeå University, Sweden .
Umeå University, Sweden .
Umeå University, Sweden .
Lund University, Sweden .
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2013 (English)In: Pediatrics, ISSN 0031-4005, E-ISSN 1098-4275, Vol. 131, no 3, E687-E694 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Between 1984 and 1996, Sweden experienced an "epidemic" of clinical celiac disease in children andlt;2 years of age, attributed partly to changes in infant feeding. Whether infant feeding affects disease occurrence and/or the clinical presentation remains unknown. We investigated and compared the total prevalence of celiac disease in 2 birth cohorts of 12-year-olds and related the findings to each cohorts ascertained infant feeding. less thanbrgreater than less thanbrgreater thanMETHODS: A 2-phase cross-sectional screening study was performed in which 13 279 children from 2 birth cohorts participated: children born during the epidemic (1993) and children born after the epidemic (1997). Previously diagnosed cases were reported and confirmed. Blood samples were analyzed for serological markers and children with positive values were referred for small intestinal biopsy. Infant feeding practices in the cohorts were ascertained via questionnaires. Prevalence comparisons were expressed as prevalence ratios. less thanbrgreater than less thanbrgreater thanRESULTS: The total prevalence of celiac disease was 29 in 1000 and 22 in 1000 for the 1993 and 1997 cohorts, respectively. Children born in 1997 had a significantly lower risk of having celiac disease compared with those born in 1993 (prevalence ratio: 0.75; 95% confidence interval: 0.60-0.93; P = .01). The cohorts differed in infant feeding (specifically, in the proportion of infants introduced to dietary gluten in small amounts during ongoing breastfeeding). less thanbrgreater than less thanbrgreater thanCONCLUSIONS: A significantly reduced prevalence of celiac disease in 12-year-olds indicates an option for disease prevention. Our findings suggest that the present infant feeding recommendation to gradually introduce gluten-containing foods from 4 months of age, preferably during ongoing breastfeeding, is favorable. Pediatrics 2013;131:e687-e694

Place, publisher, year, edition, pages
American Academy of Pediatrics , 2013. Vol. 131, no 3, E687-E694 p.
Keyword [en]
celiac disease, prevalence, infant feeding
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-90760DOI: 10.1542/peds.2012-1015ISI: 000315587400004OAI: oai:DiVA.org:liu-90760DiVA: diva2:614690
Note

Funding Agencies|European Union|FP6-2005-FOOD-4B-36383-PREVENTCD|Swedish Research Council|521-2004-7093521-2007-2953|Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning|222-2004-1918222-2007-1394|Swedish Council for Working Life and Social Research|2005-0802|

Available from: 2013-04-05 Created: 2013-04-05 Last updated: 2017-12-06

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Högberg, LottaStenhammar, Lars

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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Norrköping
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