liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2
Ulm University, Germany.
National Heart and Lung Institute, Imperial College London, UK .
Ulm University, Germany.
Prince of Wales Hospital, Chinese University of Hong Kong, China.
Show others and affiliations
2009 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 39, no 12, 1875-1888 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Common polymorphisms have been identified in genes suspected to play a role in asthma. We investigated their associations with wheeze and allergy in a case-control sample from Phase 2 of the International Study of Asthma and Allergies in Childhood.

METHODS: We compared 1105 wheezing and 3137 non-wheezing children aged 8-12 years from 17 study centres in 13 countries. Genotyping of 55 candidate single nucleotide polymorphisms (SNPs) in 14 genes was performed using the Sequenom System. Logistic regression models were fitted separately for each centre and each SNP. A combined per allele odds ratio and measures of heterogeneity between centres were derived by random effects meta-analysis.

RESULTS: Significant associations with wheeze in the past year were detected in only four genes (IL4R, TLR4, MS4A2, TLR9, P<0.05), with per allele odds ratios generally <1.3. Variants in IL4R and TLR4 were also related to allergen-specific IgE, while polymorphisms in FCER1B (MS4A2) and TLR9 were not. There were also highly significant associations (P<0.001) between SPINK5 variants and visible eczema (but not IgE levels) and between IL13 variants and total IgE. Heterogeneity of effects across centres was rare, despite differences in allele frequencies.

CONCLUSIONS: Despite the biological plausibility of IgE-related mechanisms in asthma, very few of the tested candidates showed evidence of association with both wheeze and increased IgE levels. We were unable to confirm associations of the positional candidates DPP10 and PHF11 with wheeze, although our study had ample power to detect the expected associations of IL13 variants with IgE and SPINK5 variants with eczema.

Place, publisher, year, edition, pages
John Wiley & Sons, 2009. Vol. 39, no 12, 1875-1888 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-90909DOI: 10.1111/j.1365-2222.2009.03364.xPubMedID: 20085599OAI: diva2:615030

ISAAC Phase 2 Study Group

Available from: 2013-04-08 Created: 2013-04-08 Last updated: 2013-04-09

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Allergy CentreFaculty of Health SciencesAllergy Centre UHL
In the same journal
Clinical and Experimental Allergy
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 46 hits
ReferencesLink to record
Permanent link

Direct link