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National Incidence and Prevalence of TSH-Secreting Pituitary Adenomas in Sweden
University of Gothenburg, Sweden .
Karolinska University Hospital Solna, Sweden .
Skåne University Hospital, Sweden .
Umeå University, Sweden .
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2013 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 98, no 2, 626-635 p.Article in journal (Refereed) Published
Abstract [en]

Context: TSH-secreting pituitary adenomas (TSHomas) are rare. Epidemiological data are scant and there are no reports on national incidence. less thanbrgreater than less thanbrgreater thanObjective: The objective of the study was to estimate the national Swedish incidence and prevalence of TSHomas. less thanbrgreater than less thanbrgreater thanDesign: This was an observational study. less thanbrgreater than less thanbrgreater thanSetting: The study was conducted at tertiary referral centers. less thanbrgreater than less thanbrgreater thanPatients: The Swedish Pituitary Registry and World Health Organization International Statistical Classification of Diseases and Related Health Problems coding at all university hospitals were used to identify patients diagnosed with TSHomas 1990-2010. The identified patients medical records were studied until the latest follow-up [median 5.0 years (range andlt; 1-20 years)]. less thanbrgreater than less thanbrgreater thanMain Outcome Measurements: Incidence, prevalence, demographics, tumor characteristics, treatment outcome, and thyroid hormone level at diagnosis were measured. less thanbrgreater than less thanbrgreater thanResults: The age-standardized national incidence of 28 TSHoma patients was 0.15 per 1 million inhabitants per year, with an increasing incidence over time (0.05 per 1 million per year in 1990-1994 to 0.26 per 1 million per year in 2005-2009). The national prevalence in 2010 was 2.8 per 1 million inhabitants, in which 0.85 per 1 million had active disease. Most patients (n = 22) underwent pituitary surgery, 5 had radiotherapy, and 6 had somatostatin analogues. Eighteen patients were considered cured at the latest follow-up; 25% remained uncontrolled. Subjects treated for putative primary hyperthyroidism prior to diagnosis had TSH levels more than double those with intact thyroid at diagnosis (P = .013). The median time to diagnosis was longer for women than men (4 vs andlt; 1 year, P = .026). More women than men were treated surgically (94.1% vs 54.5%, P = .022). less thanbrgreater than less thanbrgreater thanConclusion: This is the first estimate of a national incidence of TSHoma. Additional epidemiological studies are needed to compare these results with other geographical areas. This study suggests an increased incidence of TSHomas, in agreement with reports on other pituitary adenomas. (J Clin Endocrinol Metab 98: 626-635, 2013)

Place, publisher, year, edition, pages
Endocrine Society , 2013. Vol. 98, no 2, 626-635 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-91021DOI: 10.1210/jc.2012-3362ISI: 000316270900058OAI: diva2:615655

Funding Agencies|Sahlgrens Academy at Gothenburg University||Swedish Society for Medical Research, Sweden||LUA/Alf agreement of Sahlgrenska University Hospital, Gothenburg||Swedish Pituitary Registry||

Available from: 2013-04-11 Created: 2013-04-11 Last updated: 2013-10-08

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Wahlberg Topp, Jeanette
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Internal MedicineFaculty of Health SciencesDepartment of Endocrinology
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