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A child with a long-standing, intensely itching subcutaneous nodule on a thigh: an uncommon (?) reaction to commonly used vaccines
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in West Östergötland, Research & Development Unit in Local Health Care.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
Linköping University, Department of Clinical and Experimental Medicine, Allergy Centre. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Allergy Center.
2013 (English)In: BMJ Case Reports, ISSN 1757-790XArticle in journal (Refereed) Published
Abstract [en]

A 2-year-old girl presented with an intensely itching subcutaneous nodule on the front of a thigh. The nodule persisted for 10 months until it was excised. Subsequent investigation for malignancy and systemic disease showed no pathological findings. The diagnosis, persistent itching vaccination granuloma, was revealed by hazard almost 2 years after the onset of symptoms. Persistent itching subcutaneous nodules at the injection site for aluminium containing vaccines (mostly diphtheria-tetanus-pertussis combination vaccines for primary immunisation of infants) may appear with a long delay after the vaccination (months), cause prolonged itching (years) and are often associated with contact allergy to aluminium. The condition is poorly recognised in Health Care which may lead to prolonged symptoms and unnecessary investigations.

Place, publisher, year, edition, pages
BMJ Publishing Group , 2013.
Keyword [en]
itching, subcutaneous, nodule, vaccine
National Category
Pediatrics Dermatology and Venereal Diseases Family Medicine
Identifiers
URN: urn:nbn:se:liu:diva-91041DOI: 10.1136/bcr-2012-007779PubMedID: 23354861OAI: oai:DiVA.org:liu-91041DiVA: diva2:615892
Available from: 2013-04-12 Created: 2013-04-12 Last updated: 2014-03-17

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Bergfors, ElisabetLundmark, KatarzynaNyström Kronander, Ulla

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Bergfors, ElisabetLundmark, KatarzynaNyström Kronander, Ulla
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Department of Medical and Health SciencesFaculty of Health SciencesResearch & Development Unit in Local Health CareDivision of Inflammation MedicineDepartment of Clinical Pathology and Clinical GeneticsAllergy CentreAllergy Center
PediatricsDermatology and Venereal DiseasesFamily Medicine

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CiteExportLink to record
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