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Evidence for two types of brown adipose tissue in humans
Medicinsk genetik, Göteborgs universitet.
Medicinsk genetik, Göteborgs universitet.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
Medicinsk genetik, Göteborgs universitet.
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2013 (English)In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 19, no 5, 631-634 p.Article in journal (Refereed) Published
Abstract [en]

The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was commonly believed to be the equivalent of the interscapular thermogenic organ of small mammals. This view was recently disputed on the basis of the demonstration that this depot consists of beige (also called brite) brown adipocytes, a newly identified type of brown adipocyte that is distinct from the classical brown adipocytes that make up the interscapular thermogenic organs of other mammals. A combination of high-resolution imaging techniques and histological and biochemical analyses showed evidence for an anatomically distinguishable interscapular BAT (iBAT) depot in human infants that consists of classical brown adipocytes, a cell type that has so far not been shown to exist in humans. On the basis of these findings, we conclude that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.

Place, publisher, year, edition, pages
Nature Publishing Group, 2013. Vol. 19, no 5, 631-634 p.
Keyword [en]
BAT, MRI
National Category
Medical Genetics Cell and Molecular Biology Medical Image Processing Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-91307DOI: 10.1038/nm.3017ISI: 000318583000037OAI: oai:DiVA.org:liu-91307DiVA: diva2:617032
Funder
Knut and Alice Wallenberg Foundation, 2011.0059
Available from: 2013-04-21 Created: 2013-04-21 Last updated: 2017-12-06Bibliographically approved

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Dahlqvist Leinhard, OlofElander, LouiseRomu, ThobiasPersson, AndersBorga, Magnus

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Dahlqvist Leinhard, OlofElander, LouiseRomu, ThobiasPersson, AndersBorga, Magnus
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Center for Medical Image Science and Visualization (CMIV)Division of Radiological SciencesFaculty of Health SciencesDepartment of Radiation PhysicsCell BiologyMedical InformaticsThe Institute of TechnologyRadiologyDepartment of Radiology in Linköping
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Medical GeneticsCell and Molecular BiologyMedical Image ProcessingRadiology, Nuclear Medicine and Medical Imaging

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