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Association between preterm birth and intrauterine growth retardation and child asthma
Lund University, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
IVF and Fertil Clin, Sweden .
National Board Health and Welf, Sweden .
2013 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 41, no 3, 671-676 p.Article in journal (Refereed) Published
Abstract [en]

An association between preterm birth and an increased risk of childhood asthma has been demonstrated, but the importance of intrauterine growth retardation on asthma risk is unclear. less thanbrgreater than less thanbrgreater thanUsing data from Swedish health registers, infant characteristics and childhood asthma were studied. Analyses were made using Mantel-Haenszel methodology with adjustment for year of birth, maternal age, parity, smoking in early pregnancy and maternal body mass index. Preterm birth, birth weight and birth weight for gestational week were analysed and childhood asthma was evaluated from prescriptions of anti-asthmatic drugs. Neonatal respiratory problems and treatment for them were studied as mediating factors. less thanbrgreater than less thanbrgreater thanBoth short gestational duration and intrauterine growth retardation appeared to be risk factors and seemed to act separately. The largest effect was seen from short gestational duration. Use of mechanical ventilation in the newborn period and bronchopulmonary dysplasia were strong risk factors. A moderately increased risk was also seen in infants born large for gestational age. less thanbrgreater than less thanbrgreater thanWe conclude that preterm birth is a stronger risk factor for childhood asthma than intrauterine growth disturbances; however, the latter also affects the risk, and is also seen in infants born at term.

Place, publisher, year, edition, pages
European Respiratory Society: ERJ , 2013. Vol. 41, no 3, 671-676 p.
Keyword [en]
Birth weight, epidemiology, mechanical ventilation, registers, respiratory problems
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-91345DOI: 10.1183/09031936.00041912ISI: 000316158900027OAI: diva2:617246
Available from: 2013-04-22 Created: 2013-04-22 Last updated: 2013-04-22

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Finnström, Orvar
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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
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