liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Bronchial Responsiveness to Dry Air Hyperventilation in Smokers May Predict Decline in Airway Status Using Indirect Methods
County Hospital Ryhov, Sweden .
Rosenlund Primary Care Unit, Sweden .
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Clinical Physiology UHL.
2013 (English)In: Lung, ISSN 0341-2040, E-ISSN 1432-1750, Vol. 191, no 2, 183-190 p.Article in journal (Refereed) Published
Abstract [en]

Disabling respiratory symptoms and rapid decline of lung function may occur in susceptible tobacco smokers. Bronchial hyperresponsiveness (BHR) elicited by direct challenge methods predicts worse lung function outcomes. The aim of this study was to evaluate whether BHR to isocapnic hyperventilation of dry air (IHDA) was associated with rapid deterioration in airway status and respiratory symptoms. less thanbrgreater than less thanbrgreater thanOne hundred twenty-eight smokers and 26 age- and sex-matched healthy individuals with no history of smoking were investigated. All subjects completed a questionnaire. Spirometry and impulse oscillometry (IOS) measurements were recorded before and after 4 min of IHDA. The tests were repeated after 3 years in 102 smokers and 11 controls. less thanbrgreater than less thanbrgreater thanEighty-five smokers (66 %) responded to the challenge with a a parts per thousand yen2.4-Hz increase in resonant frequency (F (res)), the cutoff limit defining BHR, as recorded by IOS. They had higher F (res) at baseline compared to nonresponding smokers [12.8 +/- A 3.2 vs. 11.5 +/- A 3.4 Hz (p andlt; 0.05)] and lower FEV1 [83 +/- A 13 vs. 89 +/- A 13 % predicted (p andlt; 0.05)]. Multivariable logistic regression analysis indicated that wheezing (odds ratio = 3.7, p andlt; 0.01) and coughing (odds ratio = 8.1, p andlt; 0.05) were significantly associated with hyperresponsiveness. An increase in F (res) was recorded after 3 years in responding smokers but not in nonresponders or controls. The difference remained when subjects with COPD were excluded. less thanbrgreater than less thanbrgreater thanThe proportion of hyperresponsive smokers was unexpectedly high and there was a close association between wheezing and coughing and BHR. Only BHR could discriminate smokers with rapid deterioration of airway status from others.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2013. Vol. 191, no 2, 183-190 p.
Keyword [en]
Bronchial hyperresponsiveness, Impulse oscillometry, Isocapnic hyperventilation of dry air, Resonant frequency, Tobacco smoke
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-91339DOI: 10.1007/s00408-012-9448-yISI: 000316570900005OAI: diva2:617261

Funding Agencies|Futurum||Academy of Healthcare||Jonkoping County Council||FORSS||Medical Research Council of Southeast Sweden||

Available from: 2013-04-22 Created: 2013-04-22 Last updated: 2013-04-22

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Schmekel, Birgitta
By organisation
Clinical PhysiologyFaculty of Health SciencesDepartment of Clinical Physiology UHL
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 32 hits
ReferencesLink to record
Permanent link

Direct link