31P MRS as a Potential Biomarker for Fibromyalgia
2012 (English)In: Proceedings of the 20th Annaal Meeting & Exhibition, 5-11 May, Melbourne, Australia, 2012, 1493-1493 p.Conference paper (Refereed)
Major clinical symptoms in fibromyalgia (FM) are muscle pain, stiffness and fatigue. Studies have shown reduced voluntary strength and exercise capacity, lower endurance and more muscular pain even at low workload. An impaired muscle energy metabolism has therefore been proposed as a result of the disease. An earlier study using magnetic resonance spectroscopy (MRS) showed that at maximal dynamic and static contractions the concentration of inorganic phosphate was lower in FM . A decrease in ATP, ADP and PCr and an increase in AMP and creatine was found in FM biopsies . The purpose of this study was to non-invasively analyze the quantitative content of phosphagens in the resting muscle in FM in comparison to healthy controls using 31P MRS of the quadriceps muscle.
Place, publisher, year, edition, pages
2012. 1493-1493 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-91387OAI: oai:DiVA.org:liu-91387DiVA: diva2:617508
ISMRM, 20th Annaal Meeting & Exhibition, 5-11 May, Melbourne, Australia