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31P MRS as a Potential Biomarker for Fibromyalgia
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-4630-6550
Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Rheumatology.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Physiotherapy. Linköping University, Faculty of Health Sciences.
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2012 (English)In: Proceedings of the 20th Annaal Meeting & Exhibition, 5-11 May, Melbourne, Australia, 2012, 1493-1493 p.Conference paper, Published paper (Refereed)
Abstract [en]

Major clinical symptoms in fibromyalgia (FM) are muscle pain, stiffness and fatigue. Studies have shown reduced voluntary strength and exercise capacity, lower endurance and more muscular pain even at low workload. An impaired muscle energy metabolism has therefore been proposed as a result of the disease. An earlier study using magnetic resonance spectroscopy (MRS) showed that at maximal dynamic and static contractions the concentration of inorganic phosphate was lower in FM [1]. A decrease in ATP, ADP and PCr and an increase in AMP and creatine was found in FM biopsies [2]. The purpose of this study was to non-invasively analyze the quantitative content of  phosphagens in the resting muscle in FM in comparison to healthy controls using 31P MRS of the quadriceps muscle.

Place, publisher, year, edition, pages
2012. 1493-1493 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-91387OAI: oai:DiVA.org:liu-91387DiVA: diva2:617508
Conference
ISMRM, 20th Annaal Meeting & Exhibition, 5-11 May, Melbourne, Australia
Available from: 2013-04-23 Created: 2013-04-23 Last updated: 2014-10-02Bibliographically approved

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Forsgren, MikaelBengtsson, AnnDahlqvist Leinhard, OlofSören, BirgittaLund, EvaLundberg, Peter

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Forsgren, MikaelBengtsson, AnnDahlqvist Leinhard, OlofSören, BirgittaLund, EvaLundberg, Peter
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Center for Medical Image Science and Visualization (CMIV)Radiation PhysicsFaculty of Health SciencesDepartment of Radiation PhysicsRheumatologyDepartment of RheumatologyPhysiotherapy
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