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Is the α/β ratio for prostate tumours really low and does it vary with the level of risk at diagnosis?
University of Wisconsin Medical School, Madison, WI, USA.
Stockholm University and Karolinska Institutet, Stockholm, Sweden .ORCID iD: 0000-0002-7101-240X
Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences.ORCID iD: 0000-0001-8171-2541
2013 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 33, no 3, 1009-1011 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To answer the questions: Is the α/β ratio (radiosensitivity to size of dose-per-fraction) really low enough to justify using a few large dose fractions instead of the traditional many small doses? Does this parameter vary with prognostic risk factors? Methods and Materials: Three large statistical overviews are critiqued, with results for 5,000, 6,000 and 14,000 patients with prostate carcinoma, respectively. Results: These major analyses agree in finding the average α/β ratio to be less than 2 Gy: 1.55 (95% confidence interval=0.46-4.52), 1.4 (0.9-2.2), and the third analysis 1.7 (1.4-2.2) by ASTRO and 1.6 (1.2-2.2) by Phoenix criteria. All agree that α/β values do not vary significantly with the low, intermediate, high and “all included” risk factors. Conclusion: The high sensitivity to dose-per-fraction is an intrinsic property of prostate carcinomas and this supports the use of hypofractionation to increase the therapeutic gain for these tumours with dose-volume modelling to reduce the risk of late complications in rectum and bladder.

Place, publisher, year, edition, pages
International Institute of Anticancer Research (IIAR) , 2013. Vol. 33, no 3, 1009-1011 p.
Keyword [en]
Prostate cancer, radiation therapy, alpha/beta, LQ model
National Category
Cancer and Oncology
URN: urn:nbn:se:liu:diva-91554ISI: 000316770400034OAI: diva2:618284
Available from: 2013-04-26 Created: 2013-04-26 Last updated: 2015-05-07

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Toma-Dasu, IulianaDasu, Alexandru
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Department of Radiation PhysicsFaculty of Health SciencesDivision of Radiological Sciences
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