Natriuretic peptide proANP (1-98), a biomarker of ALI/ARDS in burns
2013 (English)In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 39, no 2, 243-248 p.Article in journal (Refereed) Published
Introduction: Plasma atrial natriuretic peptide levels (proANP (1-98)), a parameter of myocardial dysfunction, have been reported to be increased in critically ill patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). The aim of the study was to examine if proANP is a biomarker of ALI/ARDS as assessed by the Sequential Organ Failure Assessment score (SOFA Lung andgt;= 2) in burn patients, and how it compares to the corresponding values for age, total body surface area percent (TBSA%) and inhalation injury for mortality prediction. less thanbrgreater than less thanbrgreater thanMethods: A group of 22 burn patients with a mean TBSA of 30% (10-75%) and a mean age of 52 years (25-84 years) was investigated during 2010. Organ dysfunction/failure was classified according to the SOFA score. The criteria for ALI/ARDS were based on SOFA Lung andgt;= 2. ProANP (1-98) concentrations (nmol l(-1)) were measured by commercially available enzyme linked immunosorbent assay (ELISA) immunoassays (Biomedica Austria) on post-bum days 2 and 7. less thanbrgreater than less thanbrgreater thanResults: ProANP levels on day 7 post-bum positively correlated with a SOFA score day 7 post-burn, c = 0.91. The receiver operating curve (ROC) analysis proved a sensitivity of 75% and a specificity of 75% for ALI/ARDS at cut-off values andgt; 3.35 nmol l(-1). The ROC value of proANP for ALI/ARDS (SOFA Lung andgt;= 2) was significantly larger than that of age, TBSA% and inhalation injury: 0.90, 0.71, 0.74, and 0.69 (p andlt; 0.001). less thanbrgreater than less thanbrgreater thanConclusions: ProANP levels, as a biomarker of ALI/ARDS, in critically burn patients correlated with SOFA scoring. The inhalation injury did not lead to increase in proANP values.
Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 39, no 2, 243-248 p.
ProANP (1-98) levels, Plasma atrial natriuretic peptides, Inhalation injury, ALI/ARDS, SOFA score
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-91550DOI: 10.1016/j.burns.2012.06.010ISI: 000316520400007OAI: oai:DiVA.org:liu-91550DiVA: diva2:618291
Funding Agencies|Agency of the Ministry of Health of Czech Republic IGA MZ CR|NS10014-4/2008|2013-04-262013-04-262014-03-24