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Electronystagmographic findings in rats exposed to styrene or toluene
Linköping University.
Linköping University.
Linköping University.
Linköping University.
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1982 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 93, 107-112 p.Article in journal (Refereed) Published
Abstract [en]

A previously described experimental model for studying the effect of industrial solvents in the vestibular system of rabbits has been applied to rats. To achieve a constant concentration, the solvent was infused intravenously, dissolved in a lipid emulsion. Arterial blood levels were estimated by gas chromatography. The vestibulo-oculomotor behaviour of rats during repeated rotatory acceleration was investigated by electronystagmography. The effect of two solvents-toluene and styrene-on the rotatory induced nystagmus was examined. Both solvents caused an exaggerated reaction at arterial blood  levels above 75 ppm. The investigation indicated that the rat will be suitable species for further electronystagmographic investigation of the influence of organic solvents on the vestibular system, for example in screening studies of the toxicity of these solvents.

Place, publisher, year, edition, pages
1982. Vol. 93, 107-112 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-91747PubMedID: 6977982OAI: diva2:619001
Available from: 2013-05-01 Created: 2013-05-01 Last updated: 2013-05-16Bibliographically approved

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Tham, RichardLarsby, BirgittaÖdkvist, Lars
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Linköping UniversityÖstergötlands Läns Landsting
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