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The effect of toluene on the vestibulo- and opto-oculomotor system in rats: A computerized nystagmographic study
Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
1986 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 101, no 5-6, 422-428 p.Article in journal (Refereed) Published
Abstract [en]

The short-term effect of exposure to toluene on the vestibulo- and opto-oculomotor system in rats was investigated. Stimulation of the vestibulo- and opto-oculomotor system was either a constant rotatory acceleration, a sinusoidal oscillation, a randomized oscillation or an optokinetic stimulation. Eye movements in response to the different stimulations were recorded by EOG and fed into a computer for analysis. Due to toluene exposure the slow phase velocity gain during constant acceleration increased and the post-acceleratory nystagmus response was prolonged. The optokinetic gain at stimulation velocities above 10 deg/sec decreased during toluene exposure. Toluene also prolonged the duration of optokinetic after-and after-afternystagmus. The findings in this study strongly suggest an effect of toluene on the cerebellum.

 

Place, publisher, year, edition, pages
Informa Healthcare, 1986. Vol. 101, no 5-6, 422-428 p.
Keyword [en]
electro-oculography, computer analysis, solvent exposure, cerebellum
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-91759DOI: 10.3109/00016488609108627OAI: oai:DiVA.org:liu-91759DiVA: diva2:619021
Available from: 2013-05-01 Created: 2013-05-01 Last updated: 2017-12-06Bibliographically approved

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Larsby, BirgittaTham, RichardÖdkvist, Lars

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