The effect of toluene on the vestibulo- and opto-oculomotor system in rats: A computerized nystagmographic study
1986 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 101, no 5-6, 422-428 p.Article in journal (Refereed) Published
The short-term effect of exposure to toluene on the vestibulo- and opto-oculomotor system in rats was investigated. Stimulation of the vestibulo- and opto-oculomotor system was either a constant rotatory acceleration, a sinusoidal oscillation, a randomized oscillation or an optokinetic stimulation. Eye movements in response to the different stimulations were recorded by EOG and fed into a computer for analysis. Due to toluene exposure the slow phase velocity gain during constant acceleration increased and the post-acceleratory nystagmus response was prolonged. The optokinetic gain at stimulation velocities above 10 deg/sec decreased during toluene exposure. Toluene also prolonged the duration of optokinetic after-and after-afternystagmus. The findings in this study strongly suggest an effect of toluene on the cerebellum.
Place, publisher, year, edition, pages
Informa Healthcare, 1986. Vol. 101, no 5-6, 422-428 p.
electro-oculography, computer analysis, solvent exposure, cerebellum
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-91759DOI: 10.3109/00016488609108627OAI: oai:DiVA.org:liu-91759DiVA: diva2:619021