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Clock controls angiogenesis
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Karolinska Institute, Stockholm, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Karolinska Institute, Stockholm, Sweden .
2013 (English)In: Cell Cycle, ISSN 1538-4101, E-ISSN 1551-4005, Vol. 12, no 3, 405-408 p.Article, review/survey (Refereed) Published
Abstract [en]

Circadian rhythms control multiple physiological and pathological processes, including embryonic development in mammals and development of various human diseases. We have recently, in a developing zebrafish embryonic model, discovered that the circadian oscillation controls developmental angiogenesis. Disruption of crucial circadian regulatory genes, including Bmal1 and Period2, results in marked impairment or enhancement of vascular development in zebrafish. At the molecular level, we show that the circadian regulator Bmal1 directly targets the promoter region of the vegf gene in zebrafish, leading to an elevated expression of VEGF. These findings can reasonably be extended to developmental angiogenesis in mammals and even pathological angiogenesis in humans. Thus, our findings, for the first time, shed new light on mechanisms that underlie circadian clock-regulated angiogenesis.

Place, publisher, year, edition, pages
Landes Bioscience , 2013. Vol. 12, no 3, 405-408 p.
Keyword [en]
Bmal1, Clock, Period2, VEGF, angiogenesis, circadian, development, vasculature, vasculogenesis, zebrafish
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-92648DOI: 10.4161/cc.23596PubMedID: 23324349OAI: oai:DiVA.org:liu-92648DiVA: diva2:621507
Available from: 2013-05-15 Created: 2013-05-15 Last updated: 2017-12-06Bibliographically approved

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Jensen, Lasse Dahl

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