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Pathological angiogenesis facilitates tumor cell dissemination and metastasis
Karolinska Institute, Stockholm, Sweden .
Karolinska Institute, Stockholm, Sweden .
Karolinska Institute, Stockholm, Sweden .
Karolinska Institute, Stockholm, Sweden .
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2010 (English)In: Cell Cycle, ISSN 1538-4101, E-ISSN 1551-4005, Vol. 9, no 5, 913-917 p.Article in journal (Refereed) Published
Abstract [en]

Clinically detectable metastases represent an ultimate consequence of the metastatic cascade that consists of distinct processes including tumor cell invasion, dissemination, metastatic niche formation, and re-growth into a detectable metastatic mass. Although angiogenesis is known to promote tumor growth, its role in facilitating early events of the metastatic cascade remains poorly understood. We have recently developed a zebrafish tumor model that enables us to study involvement of pathological angiogenesis in tumor invasion, dissemination and metastasis. This non-invasive in vivo model allows detection of single malignant cell dissemination under both normoxia and hypoxia. Further, hypoxia-induced VEGF significantly facilitates tumor cell invasion and dissemination. These findings demonstrate that VEGF-induced pathological angiogenesis is essential for tumor dissemination and further corroborates potentially beneficial effects of clinically ongoing anti-VEGF drugs for the treatment of various malignancies.

Place, publisher, year, edition, pages
Landes Bioscience , 2010. Vol. 9, no 5, 913-917 p.
Keyword [en]
angiogenesis, hypoxia, tumor, invasion, metastasis, zebrafish
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-92660DOI: 10.4161/cc.9.5.10853PubMedID: 20160500OAI: diva2:621513
Available from: 2013-05-15 Created: 2013-05-15 Last updated: 2013-05-30Bibliographically approved

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Jensen, Lasse Dahl
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Cell Cycle
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