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B-Type Natriuretic Peptide and Prognosis in Heart Failure Patients With Preserved and Reduced Ejection Fraction
University of Groningen, Netherlands .
University of Groningen, Netherlands .
Linköping University, Department of Social and Welfare Studies, Health, Activity, Care. Linköping University, Faculty of Health Sciences.
University of Groningen, Netherlands .
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2013 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 61, no 14, 1498-1506 p.Article in journal (Refereed) Published
Abstract [en]

Objectives This study sought to determine the prognostic value of B-type natriuretic peptide (BNP) in patients with heart failure with preserved ejection fraction (HFPEF), in comparison to data in HF patients with reduced left ventricular (LV) EF (andlt;= 40%). less thanbrgreater than less thanbrgreater thanBackground Management of patients with HFPEF is difficult. BNP is a useful biomarker in patients with reduced LVEF, but data in HFPEF are scarce. less thanbrgreater than less thanbrgreater thanMethods In this study, 615 patients with mild to moderate HF (mean age 70 years, LVEF 33%) were followed for 18 months. BNP concentrations were measured at baseline and were related to the primary outcome, that is, a composite of all-cause mortality and HF hospitalization, and to mortality alone. The population was divided in quintiles, according to LVEF, and patients with reduced LVEF were compared with those with HFPEF. less thanbrgreater than less thanbrgreater thanResults There were 257 patients (42%) who had a primary endpoint and 171 (28%) who died. BNP levels were significantly higher in patients with reduced LVEF than in those with HFPEF (p andlt; 0.001). BNP was a strong predictor of outcome, but LVEF was not. Importantly, if similar levels of BNP were compared across the whole spectrum of LVEF, and for different cutoff levels of LVEF, the associated risk of adverse outcome was similar in HFPEF patients as in those with reduced LVEF. less thanbrgreater than less thanbrgreater thanConclusions BNP levels are lower in patients with HFPEF than in patients with HF with reduced LVEF, but for a given BNP level, the prognosis in patients with HFPEF is as poor as in those with reduced LVEF. (J Am Coll Cardiol 2013;61:1498-506)

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 61, no 14, 1498-1506 p.
Keyword [en]
heart failure, natriuretic peptides, preserved ejection fraction, prognosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-92605DOI: 10.1016/j.jacc.2012.12.044ISI: 000317192300006OAI: diva2:621700

Funding Agencies|Netherlands Heart Foundation|2000Z003|Biosite Europe, France||Amgen, Johnson Johnson||Novartis||Sorbent||Vifor||BG Medicine||BioControl||Alere||Bayer||Cardio3 Biosciences||Celladon||Ceva||European Commission||Dutch Heart Foundation||Servier||Torrent||

Available from: 2013-05-16 Created: 2013-05-14 Last updated: 2013-05-16

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