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Specification of absorbed dose to water using model-based dose calculation algorithms for treatment planning in brachytherapy
Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-0209-498X
2013 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 58, no 8, 2561-2579 p.Article in journal (Refereed) Published
Abstract [en]

Model-based dose calculation algorithms (MBDCAs), recently introduced in treatment planning systems (TPS) for brachytherapy, calculate tissue absorbed doses. In the TPS framework, doses have hereto been reported as dose to water and water may still be preferred as a dose specification medium. Dose to tissue medium D-med then needs to be converted into dose to water in tissue D-w,D- med. Methods to calculate absorbed dose to differently sized water compartments/cavities inside tissue, infinitesimal (used for definition of absorbed dose), small, large or intermediate, are reviewed. Burlin theory is applied to estimate photon energies at which cavity sizes in the range 1 nm-10 mm can be considered small or large. Photon and electron energy spectra are calculated at 1 cm distance from the central axis in cylindrical phantoms of bone, muscle and adipose tissue for 20, 50, 300 keV photons and photons from I-125, Yb-169 and Ir-192 sources; ratios of mass-collision-stopping powers and mass energy absorption coefficients are calculated as applicable to convert D-med into D-w,D- med for small and large cavities. Results show that 1-10 nm sized cavities are small at all investigated photon energies; 100 mu m cavities are large only at photon energies andlt;20 keV. A choice of an appropriate conversion coefficient D-w,D- med/D-med is discussed in terms of the cavity size in relation to the size of important cellular targets. Free radicals from DNA bound water of nanometre dimensions contribute to DNA damage and cell killing and may be the most important water compartment in cells implying use of ratios of mass -collision-stopping powers for converting D-med into D-w,D- med.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2013. Vol. 58, no 8, 2561-2579 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-92604DOI: 10.1088/0031-9155/58/8/2561ISI: 000317185600012OAI: oai:DiVA.org:liu-92604DiVA: diva2:621701
Conference
3rd European Workshop on Monte Carlo Treatment Planning (MCTP)
Available from: 2013-05-16 Created: 2013-05-14 Last updated: 2017-12-06

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Carlsson Tedgren, ÅsaAlm Carlsson, Gudrun

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Carlsson Tedgren, ÅsaAlm Carlsson, Gudrun
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Radiation PhysicsFaculty of Health SciencesDepartment of Radiation Physics
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