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Unexpected loss of contact allergy to aluminium induced by vaccine
Sahlgrenska University Hospital, Gothenburg, Sweden.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in the West of Östergötland, Unit of Research and Development in Local Health Care, County of Östergötland.
Sahlgrenska University Hospital, Gothenburg, Sweden.
Sahlgrenska University Hospital, Gothenburg, Sweden.
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2013 (English)In: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 68, no 5, 286-292 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

In studies in Gothenburg, Sweden, in the 1990s of an aluminium hydroxide-adsorbed pertussis toxoid vaccine, 745 of ~76 000 vaccinated children developed long-lasting itchy subcutaneous nodules at the vaccination site. Of 495 children with itchy nodules patch tested for aluminium allergy, 376 (76%) were positive.

OBJECTIVES:

To study the prognosis of the vaccine-induced aluminium allergy.

PATIENTS AND METHODS:

Two hundred and forty-one children with demonstrated aluminium allergy in the previous study were patch tested again 5-9 years after the initial test, with the same procedure as used previously.

RESULTS:

Contact allergy to aluminium was no longer demonstrable in 186 of the retested 241 children (77%). A negative test result was more common in children who no longer had itching at the vaccination site; it was also related to the age of the child, the time after the first aluminium-adsorbed vaccine dose, and the strength of the reaction in the first test.

CONCLUSIONS:

Patch test reactivity to aluminium seems to disappear or weaken with time.

Place, publisher, year, edition, pages
John Wiley & Sons, 2013. Vol. 68, no 5, 286-292 p.
Keyword [en]
aluminium; contact allergy; itchy nodules; patch test; vaccines
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:liu:diva-93232DOI: 10.1111/cod.12053ISI: 000318160800006PubMedID: 23601064OAI: oai:DiVA.org:liu-93232DiVA: diva2:623574
Available from: 2013-05-28 Created: 2013-05-28 Last updated: 2017-12-06Bibliographically approved

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Bergfors, Elisabet

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Department of Medical and Health SciencesFaculty of Health SciencesUnit of Research and Development in Local Health Care, County of Östergötland
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Contact Dermatitis
Dermatology and Venereal Diseases

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