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DEVELOPMENT AND VALIDATION OF RP-HPLC-DAD METHOD FOR DETERMINATION OF NINE DRUGS AND THEIR ELEVEN METABOLITES IN PLASMA AND URINE: PLASMA SAMPLES MEASUREMENTS
Silesian Technical University, Poland .
Silesian Technical University, Poland .
Silesian Technical University, Poland .
Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Clinical Physiology UHL.
2013 (English)In: Journal of Liquid Chromatography & Related Technologies, ISSN 1082-6076, E-ISSN 1520-572X, Vol. 36, no 12, 1597-1615 p.Article in journal (Refereed) Published
Abstract [en]

A new RP-HPLC-DAD method for determination of nine drugs and eleven metabolites in body fluids was developed. The separation of drugs and metabolites (PAR, SOT, MET, ASP, PRO, NIF, CAR, DEX, KET, PAR-S, PAR-G, MET-H, D-MET, SAL, GENT, PRO-S, D-NIF, ODMC, O-DEX, and KET-G) was achieved using Develosil RP-AQUEOUS-AR5 C30 column in 30min. The obtained MQL values (0.02 mu g/mL0.23 mu g/mL) are suitable for urine/plasma measurements. Correlation coefficient (r(2)) was higher than 0.98 for all analytes. The recoveries ranged from 72.1% to 115.2% (RSD andlt;6.4%). Chromatographic data were obtained with accuracy in the range from 0.3 to 5.6%.

Place, publisher, year, edition, pages
Taylor and Francis: STM, Behavioural Science and Public Health Titles / Taylor and Francis , 2013. Vol. 36, no 12, 1597-1615 p.
Keyword [en]
drugs, HPLC-DAD, metabolites, plasma, solid phase extraction, urine
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-93399DOI: 10.1080/10826076.2012.695309ISI: 000318071500001OAI: oai:DiVA.org:liu-93399DiVA: diva2:624476
Available from: 2013-05-31 Created: 2013-05-31 Last updated: 2017-12-06

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
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  • Other style
More styles
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  • de-DE
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  • en-US
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  • nn-NO
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  • Other locale
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  • html
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