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ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram
Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
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2013 (English)In: International journal of legal medicine (Print), ISSN 0937-9827, E-ISSN 1437-1596, Vol. 127, no 3, 579-586 p.Article in journal (Refereed) Published
Abstract [en]

P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood–brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby influencing the treatment response and toxicity of P-gp substrates like citalopram and venlafaxine. In this study, we aimed to investigate the frequency of ABCB1 genotypes in forensic autopsy cases involving these two antidepressants. Further, the distribution of ABCB1 genotypes in deaths related to intoxication was compared to cases not associated to drug intoxication. The study included 228 forensic autopsy cases with different causes and manners of deaths. The ABCB1 single nucleotide polymorphisms (SNPs) G1199A, C1236T, C3435T and G2677T/A for these individuals were determined. The SNPs C1236T and C3435T in venlafaxine-positive cases were significantly different between the intoxication cases and non-intoxications. This was not seen for cases involving citalopram, indicating that the effect of genetic variants might be substrate specific. This novel finding should, however, be confirmed in future studies with larger number of cases.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2013. Vol. 127, no 3, 579-586 p.
Keyword [en]
ABCB1, Citalopram, Forensic material, Genotype, Postmortem, Venlafaxine
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-93390DOI: 10.1007/s00414-013-0849-0ISI: 000318247100006OAI: oai:DiVA.org:liu-93390DiVA: diva2:624495
Note

Funding Agencies|National Board of Forensic Medicine in Sweden||Swedish Research Council||

Available from: 2013-05-31 Created: 2013-05-31 Last updated: 2017-12-06Bibliographically approved

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Karlsson, LouiseGreen, HenrikZackrisson, Anna LenaBengtsson, FinnJakobsen Falk, ICarlsson, BjörnAhlner, JohanKugelberg, Fredrik

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Karlsson, LouiseGreen, HenrikZackrisson, Anna LenaBengtsson, FinnJakobsen Falk, ICarlsson, BjörnAhlner, JohanKugelberg, Fredrik
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Clinical PharmacologyFaculty of Health SciencesDepartment of Clinical Pharmacology
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International journal of legal medicine (Print)
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