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Leptin and adiponectin in cord blood from children of normal weight, overweight and obese mothers
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
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2013 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 102, no 6, 620-624 p.Article in journal (Refereed) Published
Abstract [en]

Aim To study cord blood concentrations of adiponectin and leptin in children born by normal weight, overweight and obese mothers and to study these parameters in relation to a weight gain intervention programme for obese mothers. Methods Ten millilitre cord blood was collected and analysed for leptin and adiponectin concentrations in children with gestational age andgt;37weeks born by 60 normal weight, 45 overweight and 145 obese mothers. 82 obese mothers took part in a weight gain intervention programme. Results Concentrations of leptin and adiponectin were higher in cord blood from children of overweight and obese mothers compared with children of normal weight mothers (leptin: Md 13.2, 30, 3 and 90.2ng/mL respectively, pandlt;0.001; adiponectin 35.9, 205.4, 213.8ng/L pandlt;0.001). No differences were found between overweight and obese mothers. The weight gain intervention programme for obese pregnant women had significant effects on the weight gain during pregnancy but had no effects on cord blood serum concentrations of leptin and adiponectin. Conclusion Cord blood leptin and adiponectin concentrations were higher in children born by overweight or obese women compared with children of normal weight mothers. A weight gain intervention programme for obese pregnant women did not affect these results. Intrauterine exposition to high concentrations of leptin and adiponectin may play a role in weight development later in life.

Place, publisher, year, edition, pages
Wiley-Blackwell , 2013. Vol. 102, no 6, 620-624 p.
Keyword [en]
Adiponectin, Leptin, Obesity, Umbilical cord
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-94318DOI: 10.1111/apa.12202ISI: 000318562500027OAI: oai:DiVA.org:liu-94318DiVA: diva2:632002
Note

Funding Agencies|Health Research Council of the Southeast of Sweden||ALF, County Council of Ostergotland||

Available from: 2013-06-24 Created: 2013-06-24 Last updated: 2017-12-06

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Brynhildsen, JanSydsjö, GunillaBlomberg, MarieClaesson, Ing-MarieTheodorsson, ElvarNyström, Fredrik H.Sydsjö, AdamJosefsson, Ann

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Brynhildsen, JanSydsjö, GunillaBlomberg, MarieClaesson, Ing-MarieTheodorsson, ElvarNyström, Fredrik H.Sydsjö, AdamJosefsson, Ann
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Obstetrics and gynecologyFaculty of Health SciencesDepartment of Gynaecology and Obstetrics in LinköpingClinical ChemistryDepartment of Clinical ChemistryDivision of Cardiovascular MedicineDepartment of Endocrinology
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